An RCT finds pentoxifylline reduces microalbuminuria, preserves eGFR, and improves left ventricular mass index over 12 months in advanced diabetic nephropathy, using surrogate endpoints. PICO summary and commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
An open RCT finds a smart-speaker virtual assistant with a behavioural intervention reduces mental distress and improves quality of life, self-care, and HbA1c in older adults with type 2 diabetes. PICO summary and commentary.
A small exploratory study finds combining empagliflozin with linagliptin shifts urinary microbiota toward a healthy pattern in type 2 diabetes, while empagliflozin alone raises some uropathogens; infection rates were not measured. PICO summary and commentary.
An RCT finds ILM peeling during vitrectomy for proliferative diabetic retinopathy reduces epiretinal membrane formation and repeat anti-VEGF injections, but does not improve visual acuity. PICO summary and commentary.
Summary: In adults with type 2 diabetes, various glucose-lowering medications as studied in the GRADE trial showed small differences in…
A GRADE substudy finds adults adding a second drug to metformin maintain high medication adherence over 3 years with small between-drug differences, while lower adherence robustly predicts worse glycaemic control. PICO summary and commentary.
An RCT finds adding oral agents to short-term intensive insulin improves early glucose control and beta-cell measures in new type 2 diabetes, but does not improve 12-month remission rates. PICO summary and commentary.
A feasibility study finds explicit HbA1c target-setting is acceptable to patients and clinicians, with no between-group difference but improved distress and self-efficacy across groups. PICO summary and commentary.
A combined clinical and mechanistic study finds a TCM formula (Suyin Detoxification Prescription) reduces creatinine and proteinuria in diabetic nephropathy via an FXR pathway, though clinical evidence remains preliminary. PICO summary and commentary.
A randomised trial finds a brief four-session online programme reduces diabetes stigma and improves body image and coping in adults with type 1 diabetes, sustained at follow-up. PICO summary and commentary.