An observational ACCORD analysis finds higher weight-adjusted waist index is independently associated with more cardiovascular events, heart failure, and mortality in type 2 diabetes, outperforming BMI. PICO summary and commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
Summary: In patients with severe mental disorder and diabetes, physician-led medication reviews significantly reduced the number of prescribed drugs and…
The NAFLDiet trial finds both a low-carb high-PUFA diet and a healthy Nordic diet reduce liver fat versus usual care, but only the Nordic diet also improves weight, HbA1c, triglycerides, and inflammation. PICO summary and commentary.
A small crossover study finds a high-carb diet shifts exercise fuel toward carbohydrate, while low-carb diets give more time in euglycaemia and less hyperglycaemia around fasted exercise in type 1 diabetes. PICO summary and commentary.
A small 4-week RCT finds L-citrulline 6 g/day improves endothelial function, leg arterial stiffness, and glucose in type 2 diabetes, in both fasted and acute-hyperglycaemic states. PICO summary and commentary.
A 12-week RCT finds both combined training and HIIT improve glucose, body composition, and quality of life in type 2 diabetes, with HIIT favouring fasting glucose and combined training favouring insulin resistance and wellbeing. PICO summary and commentary.
A small crossover validation study finds the Vyntus CPX metabolic cart gives indirect-calorimetry measurements comparable to the Vmax Encore 29N in type 2 diabetes, with only minor differences. PICO summary and commentary.
A secondary analysis finds women with gestational diabetes reach similar BMI to unaffected women by 3 years postpartum, but their children are twice as likely to be overweight despite comparable diets. PICO summary and commentary.
Summary: In patients with type 2 diabetes inadequately controlled on metformin (n=60), adding sitagliptin 100 mg/day to metformin 2000 mg/day…
Summary: In patients with type 2 diabetes inadequately controlled on metformin and glyburide (n=32), sitagliptin add-on therapy for 6 months…