Osteoporosis, vitamin D, calcium and parathyroid disorders, and bone-health therapeutics.
In a J Clin Endocrinol Metab randomized trial, Treatment with ROMO significantly increased lumbar spine BMD in glucocorticoid-treated patients, suggesting that ROMO is effective for GIOP. Key reported results included Eleven patients were assigned to the ROMO group, 14 to the DMAb group, and 14 to...
In early postmenopausal women aged 50 to 60 years, zoledronate at baseline and 5 years reduced 10-year morphometric vertebral fractures from 11.1% to 6.3%.
A double-blind RCT finds vitamin D improves insulin secretion and HOMA-IR but not fasting glucose in women with prediabetes. PICO summary and clinical expert commentary.
An RCT finds low-carb and Mediterranean diets do not significantly alter bone turnover markers in young people with type 1 diabetes. PICO summary and expert commentary.
A translational study finds rhPTH(1-34) outperforms alendronate for bone density in diabetic osteoporosis, a low-turnover state. PICO summary and expert commentary for clinicians.
The SLowDOWN phase III RCT finds sitagliptin preserves hip bone density in women with type 2 diabetes. PICO summary and expert commentary for clinicians.
The large D-Health trial finds monthly vitamin D does not prevent hypertension, high cholesterol, or type 2 diabetes in replete older adults. PICO summary and expert commentary.
A randomised trial finds parathyroid ischaemic preconditioning does not reduce hypoparathyroidism after thyroidectomy, with only an exploratory recovery signal. PICO summary and commentary.
A 24-week RCT finds neither a low-carbohydrate nor a Mediterranean diet significantly changes bone turnover markers in young people with type 1 diabetes, an exploratory null result. PICO summary and commentary.
A prospective RCT finds an improved ultrasound-guided RFA protocol with hydrodissection achieves higher clinical success and far less recurrent laryngeal nerve injury in secondary hyperparathyroidism. PICO summary and commentary.
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