Metabolic syndrome, insulin resistance, prediabetes physiology, and cardiometabolic risk.
A post-hoc analysis of the SPRINT trial finds a higher triglyceride-glucose index is associated with greater cardiovascular risk in controlled hypertension, significant only under standard blood pressure treatment. PICO summary and expert commentary.
A 7-week double-blind RCT found aripiprazole caused significantly less weight gain than risperidone in schizophrenia, with appetite changes as an early metabolic signal. PICO summary and expert commentary.
A 93-patient Turkish RCT testing whether more frequent dietitian counseling, with weekly telehealth added, improves cardiometabolic outcomes in metabolic syndrome. PICO summary and expert commentary.
The DREAM trial demonstrated that rosiglitazone reduces incident diabetes or death by 60% and achieves normoglycaemia in 50% of high-risk adults with impaired glucose tolerance, the largest pharmacological diabetes prevention effect documented in a large RCT, but the drug's subsequent cardiovascular safety concerns and market withdrawal have prevented translation of these findings into clinical practice.
A double-blind RCT finds vitamin D improves insulin secretion and HOMA-IR but not fasting glucose in women with prediabetes. PICO summary and clinical expert commentary.
A three-arm RCT shows adding a high-protein, low-GI diet to training cuts IL-6 and hs-CRP and improves insulin sensitivity in men with abdominal obesity. PICO summary and commentary.
A crossover nutrigenomics trial finds elderberry juice broadens meal-responsive gene expression in overweight adults, but measures no clinical endpoints. PICO summary and commentary.
A baseline report from a Kenyan fermented-foods trial finds heavy cardiometabolic risk clustering in prediabetes; the intervention effect is not yet tested. PICO summary and commentary.
A small crossover trial finds a mulberry leaf and corn silk functional milk lowers postprandial glucose only in an overweight prediabetic subgroup. PICO summary and expert commentary.
A four-arm RCT finds combining training with a polyphenol supplement improves prediabetes markers most, with exercise the main driver. PICO summary and expert commentary.
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