A post-hoc analysis of the SPRINT trial finds a higher triglyceride-glucose index is associated with greater cardiovascular risk in controlled hypertension, significant only under standard blood pressure treatment. PICO summary and expert commentary.
Browsing: Metabolic Syndrome & Insulin Resistance
Metabolic syndrome, insulin resistance, prediabetes physiology, and cardiometabolic risk.
A 7-week double-blind RCT found aripiprazole caused significantly less weight gain than risperidone in schizophrenia, with appetite changes as an early metabolic signal. PICO summary and expert commentary.
A 93-patient Turkish RCT testing whether more frequent dietitian counseling, with weekly telehealth added, improves cardiometabolic outcomes in metabolic syndrome. PICO summary and expert commentary.
A phase III post hoc analysis finds enavogliflozin lowers leptin and improves insulin resistance independent of weight loss in type 2 diabetes. PICO summary and expert commentary.
The DREAM trial demonstrated that rosiglitazone reduces incident diabetes or death by 60% and achieves normoglycaemia in 50% of high-risk adults with impaired glucose tolerance, the largest pharmacological diabetes prevention effect documented in a large RCT, but the drug’s subsequent cardiovascular safety concerns and market withdrawal have prevented translation of these findings into clinical practice.
A double-blind RCT finds vitamin D improves insulin secretion and HOMA-IR but not fasting glucose in women with prediabetes. PICO summary and clinical expert commentary.
A three-arm RCT shows adding a high-protein, low-GI diet to training cuts IL-6 and hs-CRP and improves insulin sensitivity in men with abdominal obesity. PICO summary and commentary.
A crossover nutrigenomics trial finds elderberry juice broadens meal-responsive gene expression in overweight adults, but measures no clinical endpoints. PICO summary and commentary.
A baseline report from a Kenyan fermented-foods trial finds heavy cardiometabolic risk clustering in prediabetes; the intervention effect is not yet tested. PICO summary and commentary.
A small crossover trial finds a mulberry leaf and corn silk functional milk lowers postprandial glucose only in an overweight prediabetic subgroup. PICO summary and expert commentary.