Dapagliflozin Plus Calorie Restriction Increased Type 2 Diabetes Remission in Early Disease
In overweight or obese adults with early type 2 diabetes, dapagliflozin added to calorie restriction increased 12-month remission from 28% to 44%.
Nutrition & Lifestyle
Diet, physical activity, behavioural and lifestyle interventions for metabolic and endocrine health.
Does the Diabetes Conversation Map Improve Knowledge and Self-Management in Type 2 Diabetes?
A single-centre Egyptian RCT found the Diabetes Conversation Map programme improved diabetes knowledge, self-management, and self-efficacy questionnaire scores versus standard education (p < 0.001), with no clinical endpoints reported. PICO summary and expert commentary.
Weight Programme in Pregnancy Improved Behaviours but Not Pregnancy Outcomes (RCT)
A randomised controlled trial of a psychosocial weight-management programme in overweight or obese pregnant women improved diet and activity but not gestational diabetes, preeclampsia, or caesarean rates. PICO summary and expert commentary.
Can a CBT-Based Digital Diet Program Improve Postprandial Glucose in Gestational Diabetes?
A multicentre randomised trial testing a CBT-based WeChat dietary programme against standard care for postprandial glucose and pregnancy outcomes in gestational diabetes. PICO summary and expert commentary.
Group-Based Nutrition Sessions for Obesity in Brazil’s Primary Care: Preliminary Reach and Adherence
A Brazilian randomized community trial reports preliminary reach and adherence for group-based nutrition interventions in primary care obesity management. PICO summary and expert commentary.
Does 4:3 Intermittent Fasting Improve Eating Behaviors Versus Daily Calorie Restriction?
A secondary analysis of a 12-month randomized trial found 4:3 intermittent fasting improved binge and uncontrolled eating versus daily calorie restriction, with no difference in appetite hormones. PICO summary and expert commentary.
Can Gut Bacteria Like Faecalibacterium Boost Weight Loss?
A 6-month randomized sub-analysis found that a multicomponent weight-loss program shifted gut microbiota and linked Faecalibacterium abundance to fat-mass loss, though causation was not established. PICO summary and expert commentary.
Home Versus Gym Exercise in Older Adults With Obesity: A Lockdown Secondary Analysis
A small non-randomised secondary analysis comparing home- and gym-based exercise in older adults with obesity during COVID-19 lockdowns, with PICO summary and expert commentary.
Does an 8-Week Intensive Exercise Protocol Help Adults With Obesity? A Small Pilot RCT
A 30-participant pilot randomised trial of an 8-week intensive exercise protocol versus diet plus brisk walking in young adults with obesity, with PICO summary and expert commentary.
Can a Family-Centered Empowerment Program Improve Diabetes Self-Management and Illness Acceptance?
A small single-blind RCT found that a family-centered empowerment program raised illness acceptance and self-management scores at six weeks in adults with type 2 diabetes. PICO summary and expert commentary.