The EDIC study demonstrated that 6.5 years of intensive glycaemic therapy during the DCCT reduced cardiovascular events by 42–57% over 17 years of follow-up despite subsequent HbA1c convergence between groups, establishing the concept of metabolic memory and providing foundational evidence that early intensive glycaemic control produces durable cardiovascular protection extending decades beyond the intervention period.
Browsing: Type 1 Diabetes
The Diabetes Control and Complications Trial demonstrated that intensive insulin therapy targeting near-normal blood glucose reduced the risk of developing retinopathy by 76% in primary prevention and slowed progression by 54% in secondary intervention, while also substantially reducing nephropathy and neuropathy, establishing the foundational evidence for tight glycaemic control in type 1 diabetes.
A pilot RCT finds prebiotic inulin enriches SCFA-producing gut bacteria but does not improve HbA1c in Indian children with type 1 diabetes. PICO summary and expert commentary.
An RCT finds low-carb and Mediterranean diets do not significantly alter bone turnover markers in young people with type 1 diabetes. PICO summary and expert commentary.
A clamp-based RCT finds metformin does not reduce hepatic insulin resistance in type 1 diabetes, arguing against its use as an insulin-sensitiser. PICO summary and commentary.
The FINE-ONE NEJM trial finds finerenone reduces albuminuria in type 1 diabetes and CKD, a surrogate-based extension of its type 2 benefits. PICO summary and commentary.
A randomised trial finds a brief four-session online programme reduces diabetes stigma and improves body image and coping in adults with type 1 diabetes, sustained at follow-up. PICO summary and commentary.
A large international RCT finds automated insulin delivery (MiniMed 670G/770G) improves HbA1c in those above 8% and reduces hypoglycaemia in those at target versus multiple daily injections in type 1 diabetes. PICO summary and commentary.
A 24-week RCT finds neither a low-carbohydrate nor a Mediterranean diet significantly changes bone turnover markers in young people with type 1 diabetes, an exploratory null result. PICO summary and commentary.
A qualitative study of parents and caregivers of adolescents with type 1 diabetes identifies their needs before transition to adult care, generating four themes to refine a future trial. PICO summary and commentary.