A GRADE substudy finds adults adding a second drug to metformin maintain high medication adherence over 3 years with small between-drug differences, while lower adherence robustly predicts worse glycaemic control. PICO summary and commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
An RCT finds adding oral agents to short-term intensive insulin improves early glucose control and beta-cell measures in new type 2 diabetes, but does not improve 12-month remission rates. PICO summary and commentary.
A feasibility study finds explicit HbA1c target-setting is acceptable to patients and clinicians, with no between-group difference but improved distress and self-efficacy across groups. PICO summary and commentary.
A combined clinical and mechanistic study finds a TCM formula (Suyin Detoxification Prescription) reduces creatinine and proteinuria in diabetic nephropathy via an FXR pathway, though clinical evidence remains preliminary. PICO summary and commentary.
A randomised trial finds a brief four-session online programme reduces diabetes stigma and improves body image and coping in adults with type 1 diabetes, sustained at follow-up. PICO summary and commentary.
A large international RCT finds automated insulin delivery (MiniMed 670G/770G) improves HbA1c in those above 8% and reduces hypoglycaemia in those at target versus multiple daily injections in type 1 diabetes. PICO summary and commentary.
An RCT finds adding a 2-3 week course of intravenous alprostadil to standard care improves the clinical response rate and lipids in diabetic foot or neuropathy, though the trial was unblinded. PICO summary and commentary.
A 24-week RCT finds Bluetooth-enabled glucometers do not improve glucose control over traditional glucometers in telehealth insulin titration, though they reduce emergency department visits. PICO summary and commentary.
A 24-week RCT finds neither a low-carbohydrate nor a Mediterranean diet significantly changes bone turnover markers in young people with type 1 diabetes, an exploratory null result. PICO summary and commentary.
Summary: In pregnant women with gestational diabetes mellitus (GDM), real-time continuous glucose monitoring (CGM) did not improve the primary composite…