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Evidence summaries in diabetes, endocrinology, and metabolism for clinicians who need the key data fast.

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Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes (PRISM): A Randomized Controlled Trial in Chinese Patients With Young-Onset Diabetes.

In a Diabetes Care randomized trial, A 3-year technology-enhanced, multicomponent program improved cardiometabolic status, proxies of β-cell function, and PROMs in individuals with YOD but did not reduce complications. Key reported results included During 2020 to 2021, 884 participants (mean [SD]...

Ultra-Rapid Lispro Has an Improved Pharmacokinetic Profile for Exercise Compared With Lispro, Resulting in Less Exercise-Associated Hypoglycemia in Adults With Type 1 Diabetes on Open-Loop Continuous Subcutaneous Insulin Infusion.

In a Diabetes Care randomized trial, Using URLi in conventional CSII pump therapy provides more effective BRRs prior to exercise compared with lispro, with fewer hypoglycemic events in active adults with type 1 diabetes. Key reported results included Twenty-five participants (mean ± SD age 36.7 ±...

Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly.

In a Diabetes Care randomized trial, Semaglutide significantly improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and promoted substantial weight loss in patients with antipsychotic-induced metabolic disturbances. Key reported results included Participants (56%...

RCT Diabetes & Glycaemic Control

Diabetes Body Project: Acute Effects of an Eating Disorder Prevention Program for Young Women With Type 1 Diabetes. A Multinational Randomized Controlled Trial.

In a Diabetes Care randomized trial, The Diabetes Body Project produced significantly larger acute effects with small to medium effect sizes compared with educational controls and has potential for broad implementation. Key reported results included Compared with educational controls (n = 146)...

RCT Diabetes & Glycaemic Control

Results From a Randomized Trial of Intensive Glucose Management Using CGM Versus Usual Care in Hospitalized Adults With Type 2 Diabetes: The TIGHT Study.

In a Diabetes Care randomized trial, The study's glucose management approach using CGM did not improve glucose levels compared with standard glucose management in the non-intensive care unit hospital setting. Key reported results included For the 110 participants included in the primary analysis...

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