Oral Agents Did Not Match Insulin for Gestational Diabetes Outcomes
In gestational diabetes requiring medication, metformin-first oral therapy with glyburide rescue did not prove noninferior to insulin for preventing large-for-gestational-age birth.
Reproductive Endocrinology
PCOS, hypogonadism, fertility, menopause, and hormone therapy.
Can HIIT and Mindful Breathing Improve Health in Obese Postmenopausal Women?
An RCT reports HIIT plus mindfulness breathing improves metabolic, hormonal, and tumour-marker profiles in obese postmenopausal women. PICO summary and critical expert commentary.
Can Time-Restricted Eating and Tai Chi Improve Heart and Metabolic Health in Postmenopausal Women?
An RCT finds adding Tai Chi to time-restricted eating improves lipids and endothelial function in postmenopausal women. PICO summary and expert commentary for clinicians.
Does Honey-Sweetened Yogurt Reduce Inflammation in Postmenopausal Women?
A crossover trial finds honey-sweetened yogurt does not change the primary inflammatory marker in postmenopausal women, with only a single secondary signal. PICO summary and commentary.
Does Vitamin D Supplementation Improve IVF Outcomes in Women with PCOS?
A large BMJ trial finds vitamin D before IVF raises blood levels but does not improve live birth rates in women with PCOS. PICO summary and expert commentary.
Can Electroacupuncture Improve Weight, Metabolism, and Quality of Life in Obese PCOS Patients?
A sham-controlled, blinded RCT finds electroacupuncture modestly reduces BMI and improves metabolic markers and quality of life in obese PCOS, sustained to 24 weeks. PICO summary and commentary.
Does Green Tea Extract Reduce Inflammation in Overweight Postmenopausal Women?
A secondary analysis of the Minnesota Green Tea Trial finds high-dose green tea extract does not reduce inflammatory markers in overweight postmenopausal women, a robust null result. PICO summary and commentary.
Is Combining Metformin and Liraglutide Effective for PCOS and Gut Health?
An open-label RCT finds combining metformin and liraglutide reduces weight, visceral fat, and free testosterone more than metformin alone in PCOS, with a rat study suggesting a gut-microbiota mechanism. PICO summary and commentary.
Can Interval Training Lower Fat Levels After Meals in Postmenopausal Women?
A small crossover study finds high- and moderate-intensity interval exercise equally reduce post-meal triglycerides in postmenopausal women, with moderate intensity better tolerated. PICO summary and commentary.
