Can PEG-Loxe Help Super-Obese Patients with Type 2 Diabetes Lose Weight?
An RCT finds the weekly GLP-1 agonist PEG-Loxe produces large dose-dependent weight loss in super-obese patients with type 2 diabetes. PICO summary and expert commentary.
Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
Can a Fat-Rich Snack Before a Carb Meal Affect Blood Sugar After Sleeve Gastrectomy?
A proof-of-concept crossover study finds a fat preload does not change postprandial glucose after sleeve gastrectomy, but raises insulin. PICO summary and commentary.
How does empagliflozin affect inflammation timing in macrophages from post-heart attack diabetics?
An ex-vivo study finds early empagliflozin dampens NLRP3 inflammasome activity in macrophages from post-MI diabetic patients, a mechanistic signal. PICO summary and commentary.
Can Pentoxifylline Protect the Kidneys and Heart in Diabetic Patients?
An RCT finds pentoxifylline reduces microalbuminuria, preserves eGFR, and improves left ventricular mass index over 12 months in advanced diabetic nephropathy, using surrogate endpoints. PICO summary and commentary.
Can a Virtual Assistant Improve Diabetes Care for Older Adults?
An open RCT finds a smart-speaker virtual assistant with a behavioural intervention reduces mental distress and improves quality of life, self-care, and HbA1c in older adults with type 2 diabetes. PICO summary and commentary.
Can Combining SGLT2 and DPP-4 Inhibitors Normalize Urinary Microbiota in Type 2 Diabetes?
A small exploratory study finds combining empagliflozin with linagliptin shifts urinary microbiota toward a healthy pattern in type 2 diabetes, while empagliflozin alone raises some uropathogens; infection rates were not measured. PICO summary and commentary.
Does ILM Peeling Improve Outcomes After Vitrectomy in Diabetic Retinopathy?
An RCT finds ILM peeling during vitrectomy for proliferative diabetic retinopathy reduces epiretinal membrane formation and repeat anti-VEGF injections, but does not improve visual acuity. PICO summary and commentary.
Is Medication Adherence Linked to Blood Sugar Control in Type 2 Diabetes?
A GRADE substudy finds adults adding a second drug to metformin maintain high medication adherence over 3 years with small between-drug differences, while lower adherence robustly predicts worse glycaemic control. PICO summary and commentary.
Can Adding Oral Medications to Short-Term Insulin Improve Diabetes Remission?
An RCT finds adding oral agents to short-term intensive insulin improves early glucose control and beta-cell measures in new type 2 diabetes, but does not improve 12-month remission rates. PICO summary and commentary.