Weekly Methotrexate Increased Antithyroid-Drug Withdrawal in Graves Disease
In an open-label Graves disease RCT, methotrexate 10 mg weekly added to methimazole increased treatment withdrawal at 18 months, but remains investigational.
Thyroid
Hypothyroidism, hyperthyroidism, thyroid nodules and cancer, and thyroid function in clinical practice.
IoN Trial: Radioiodine Could Be Avoided After Surgery for Low-Risk Thyroid Cancer
In the IoN non-inferiority RCT, omitting postoperative radioiodine after total thyroidectomy produced 5-year recurrence-free survival of 97.9% versus 96.3% with ablation in selected low-risk thyroid cancer.
Does Magnesium Affect Levothyroxine Absorption?
A healthy-volunteer pharmacokinetic crossover trial found magnesium aspartate reduced levothyroxine absorption by 12 percent, while magnesium citrate had a smaller, non-significant effect. PICO summary and expert commentary.
Does Ischemic Preconditioning Help Parathyroid Recovery After Thyroid Surgery?
A randomised trial finds parathyroid ischaemic preconditioning does not reduce hypoparathyroidism after thyroidectomy, with only an exploratory recovery signal. PICO summary and commentary.
Can Pre-Surgery Calcium and Magnesium Improve Recovery After Thyroidectomy?
A small RCT finds preoperative calcium and magnesium before thyroidectomy yields numerically lower hypocalcaemia and earlier recovery in Graves' patients, but the differences were not significant. PICO summary and commentary.
Can MRI Track Hashimoto’s Thyroiditis Improvements After Diet Changes?
A small randomised study finds dietary management reduces quantitative thyroid MRI inflammation markers and antibodies in Hashimoto's thyroiditis, though the diet is unspecified. PICO summary and commentary.
Does an Extra Levothyroxine Dose During Ramadan Help Keep TSH in Range?
A 103-patient randomized trial tested an extra 25 mcg of levothyroxine during Ramadan against standard weight-based dosing in hypothyroidism. PICO summary and expert commentary.
Clinical Pharmacist Input in Hypothyroidism: A Small RCT of Drug-Related Problems and Adherence
A 43-patient single-centre open-label RCT found clinical pharmacist review reduced drug-related problems within the intervention arm but showed no significant between-group difference in overall levothyroxine adherence. PICO summary and expert commentary.
Levothyroxine vs LT4-LT3 After Thyroidectomy: A Feasibility Trial
A 24-week double-blind feasibility trial (n=12) found LT4 monotherapy did not normalize free T4 and total T3 after thyroidectomy while LT4-LT3 did, but weight and cholesterol differences were non-significant. PICO summary and expert commentary.