Browsing: Thyroid

ORBIT found no composite responders with secukinumab or placebo in active Graves orbitopathy. Read the PICO, limitations and clinical implications.

In an open-label Graves disease RCT, methotrexate 10 mg weekly added to methimazole increased treatment withdrawal at 18 months, but remains investigational.

In the IoN non-inferiority RCT, omitting postoperative radioiodine after total thyroidectomy produced 5-year recurrence-free survival of 97.9% versus 96.3% with ablation in selected low-risk thyroid cancer.

A healthy-volunteer pharmacokinetic crossover trial found magnesium aspartate reduced levothyroxine absorption by 12 percent, while magnesium citrate had a smaller, non-significant effect. PICO summary and expert commentary.

A randomised trial finds parathyroid ischaemic preconditioning does not reduce hypoparathyroidism after thyroidectomy, with only an exploratory recovery signal. PICO summary and commentary.

A small RCT finds preoperative calcium and magnesium before thyroidectomy yields numerically lower hypocalcaemia and earlier recovery in Graves’ patients, but the differences were not significant. PICO summary and commentary.

A small randomised study finds dietary management reduces quantitative thyroid MRI inflammation markers and antibodies in Hashimoto’s thyroiditis, though the diet is unspecified. PICO summary and commentary.

Summary: In 40 patients with confirmed Hashimoto’s thyroiditis (elevated antibodies and characteristic features), structured dietary intervention targeting thyroid health and…

A 103-patient randomized trial tested an extra 25 mcg of levothyroxine during Ramadan against standard weight-based dosing in hypothyroidism. PICO summary and expert commentary.

A 43-patient single-centre open-label RCT found clinical pharmacist review reduced drug-related problems within the intervention arm but showed no significant between-group difference in overall levothyroxine adherence. PICO summary and expert commentary.