In an open-label Graves disease RCT, methotrexate 10 mg weekly added to methimazole increased treatment withdrawal at 18 months, but remains investigational.
Browsing: Thyroid
Hypothyroidism, hyperthyroidism, thyroid nodules and cancer, and thyroid function in clinical practice.
In the IoN non-inferiority RCT, omitting postoperative radioiodine after total thyroidectomy produced 5-year recurrence-free survival of 97.9% versus 96.3% with ablation in selected low-risk thyroid cancer.
A healthy-volunteer pharmacokinetic crossover trial found magnesium aspartate reduced levothyroxine absorption by 12 percent, while magnesium citrate had a smaller, non-significant effect. PICO summary and expert commentary.
A randomised trial finds parathyroid ischaemic preconditioning does not reduce hypoparathyroidism after thyroidectomy, with only an exploratory recovery signal. PICO summary and commentary.
A small RCT finds preoperative calcium and magnesium before thyroidectomy yields numerically lower hypocalcaemia and earlier recovery in Graves’ patients, but the differences were not significant. PICO summary and commentary.
A small randomised study finds dietary management reduces quantitative thyroid MRI inflammation markers and antibodies in Hashimoto’s thyroiditis, though the diet is unspecified. PICO summary and commentary.
Summary: In 40 patients with confirmed Hashimoto’s thyroiditis (elevated antibodies and characteristic features), structured dietary intervention targeting thyroid health and…
A 103-patient randomized trial tested an extra 25 mcg of levothyroxine during Ramadan against standard weight-based dosing in hypothyroidism. PICO summary and expert commentary.
A 43-patient single-centre open-label RCT found clinical pharmacist review reduced drug-related problems within the intervention arm but showed no significant between-group difference in overall levothyroxine adherence. PICO summary and expert commentary.
A 24-week double-blind feasibility trial (n=12) found LT4 monotherapy did not normalize free T4 and total T3 after thyroidectomy while LT4-LT3 did, but weight and cholesterol differences were non-significant. PICO summary and expert commentary.