Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
An RCT finds telemedicine-based home care achieves wound healing comparable to in-person care for diabetic foot ulcers, with no significant difference in healing but better self-management. PICO summary and commentary.
A machine-learning analysis of the VISTA trial finds aflibercept better preserves photoreceptor ellipsoid-zone integrity and reduces retinal fluid than laser in diabetic macular edema, with structure correlating with vision. PICO summary and commentary.
The FIVE-STAR mechanistic trial finds finerenone does not change arterial stiffness but reduces albuminuria in diabetic kidney disease, pointing to an intraglomerular-pressure mechanism. PICO summary and commentary.
A multicentre RCT finds adding cryopreserved amniotic membrane to standard care does not significantly improve healing in complex diabetic foot ulcers, though both arms healed well and it was safe. PICO summary and commentary.
A feasibility pilot finds a definitive trial of shockwave therapy for diabetic foot ulcers is deliverable, with only a descriptive (not powered) trend toward faster healing at the higher dose. PICO summary and commentary.
An RCT finds low-power laser therapy improves quality-of-life problem scores in diabetic polyneuropathy, but the neuropathy-severity difference between groups was not significant. PICO summary and commentary.
A large RCT finds a nutritionist-designed Mediterranean diet video improves adherence and reduces gestational diabetes from 25.1% to 20.7%, with fewer adverse outcomes. PICO summary and commentary.
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