A 10-week RCT finds plant- and animal-protein calorie-restricted diets both improve metabolic syndrome, with no significant between-group differences except adropin. PICO summary and commentary.
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An RCT finds telemedicine-based home care achieves wound healing comparable to in-person care for diabetic foot ulcers, with no significant difference in healing but better self-management. PICO summary and commentary.
A machine-learning analysis of the VISTA trial finds aflibercept better preserves photoreceptor ellipsoid-zone integrity and reduces retinal fluid than laser in diabetic macular edema, with structure correlating with vision. PICO summary and commentary.
The FIVE-STAR mechanistic trial finds finerenone does not change arterial stiffness but reduces albuminuria in diabetic kidney disease, pointing to an intraglomerular-pressure mechanism. PICO summary and commentary.
Summary: In patients with complex diabetic foot ulcers (DFUs) involving exposed bone, tendon, muscle, and/or joint capsule with controlled osteomyelitis…
A multicentre RCT finds adding cryopreserved amniotic membrane to standard care does not significantly improve healing in complex diabetic foot ulcers, though both arms healed well and it was safe. PICO summary and commentary.
Summary: In young patients with obesity and generalized gingivitis, systemic administration of cerium oxide nanoparticles (Cerera) for 10 days following…
Summary: In adults with obesity and/or type 2 diabetes (mean age 47.9 years, 74% female) referred for physical activity intervention,…
An RCT finds a gamified digital activity programme increases daily steps more than supervised face-to-face exercise in obesity, but with marked individual variability and no clinical-outcome or cost difference. PICO summary and commentary.
Summary: In pregnant women diagnosed with hyperglycemia during pregnancy, a behavioral physical activity intervention promoting unsupervised moderate-intensity walking or stepping…