A 7-month crossover trial finds a dietary phytomix (Dibifree) reduces HbA1c and glucose and body fat in type 2 diabetes, with effects sustained after washout, though the study was biotech-affiliated. PICO summary and commentary.
Browsing: PICO
A feasibility pilot finds remote walking coaching is acceptable and mitigates late-pregnancy activity decline in pregnancy hyperglycaemia, with only a preliminary suggestion of neonatal benefit. PICO summary and commentary.
A pilot study finds a computer-vision food-photo app estimates energy intake about as well as 24-hour recall, but both underestimate true intake versus measured expenditure. PICO summary and commentary.
A prospective RCT finds an improved ultrasound-guided RFA protocol with hydrodissection achieves higher clinical success and far less recurrent laryngeal nerve injury in secondary hyperparathyroidism. PICO summary and commentary.
A small crossover study finds high- and moderate-intensity interval exercise equally reduce post-meal triglycerides in postmenopausal women, with moderate intensity better tolerated. PICO summary and commentary.
A small RCT finds preoperative calcium and magnesium before thyroidectomy yields numerically lower hypocalcaemia and earlier recovery in Graves’ patients, but the differences were not significant. PICO summary and commentary.
An RCT finds HIIT combined with a dietitian-designed diet improves body composition, cardiovascular and endothelial function, and lipids more than exercise alone in overweight children. PICO summary and commentary.
An RCT finds healthier canteen lunches plus dietary advice cut metabolic syndrome prevalence by 30.4% in working men, far exceeding health education alone. PICO summary and commentary.
A 12-week trial finds aerobic, Tabata, and HIIT all reduce body fat and circulating hepatokines in obese men, with higher-intensity protocols producing the greatest reductions. PICO summary and commentary.
A first-in-human phase 1 study finds the FGF21 analog zalfermin supports weekly dosing and improves lipids in healthy men. PICO summary and expert commentary.