A secondary analysis finds women with gestational diabetes reach similar BMI to unaffected women by 3 years postpartum, but their children are twice as likely to be overweight despite comparable diets. PICO summary and commentary.
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A prespecified SELECT analysis finds semaglutide’s cardiovascular benefit is largely independent of weight loss, with only a third mediated by waist reduction. PICO summary and commentary.
SYNCHRONIZE-1 reports baseline characteristics of a phase 3 survodutide obesity trial; efficacy results are pending. PICO summary and expert commentary.
A SURMOUNT-5 analysis finds tirzepatide and semaglutide improve physical quality of life in obesity, with neither improving mental-health scores. PICO summary and expert commentary.
The phase 2b IMPACT trial finds weekly pemvidutide resolves MASH but does not significantly improve fibrosis at 24 weeks. PICO summary and expert commentary.
Summary: In adults with overweight or obesity following 7-day vancomycin treatment, 2′-fucosyllactose (2′-FL) supplementation for 8 weeks transiently improved gut…
Summary: In patients with type 2 diabetes inadequately controlled on metformin (n=60), adding sitagliptin 100 mg/day to metformin 2000 mg/day…
Summary: In patients with type 2 diabetes inadequately controlled on metformin and glyburide (n=32), sitagliptin add-on therapy for 6 months…
Summary: In adults with type 2 diabetes (n=40), Dibifree dietary phytomix (15 g/day) as add-on therapy significantly reduced HbA1c, fasting/postprandial…
An 8-week RCT finds a hibiscus-inulin shot produces small reductions in lipid-glucose indices in overweight adults, but the authors stress these reflect analytical responsiveness, not proven clinical benefit. PICO summary and commentary.