Browsing: Metabolism

The NAFLDiet trial finds both a low-carb high-PUFA diet and a healthy Nordic diet reduce liver fat versus usual care, but only the Nordic diet also improves weight, HbA1c, triglycerides, and inflammation. PICO summary and commentary.

A small crossover study finds a high-carb diet shifts exercise fuel toward carbohydrate, while low-carb diets give more time in euglycaemia and less hyperglycaemia around fasted exercise in type 1 diabetes. PICO summary and commentary.

A small 4-week RCT finds L-citrulline 6 g/day improves endothelial function, leg arterial stiffness, and glucose in type 2 diabetes, in both fasted and acute-hyperglycaemic states. PICO summary and commentary.

A 12-week RCT finds both combined training and HIIT improve glucose, body composition, and quality of life in type 2 diabetes, with HIIT favouring fasting glucose and combined training favouring insulin resistance and wellbeing. PICO summary and commentary.

A prespecified SELECT analysis finds semaglutide’s cardiovascular benefit is largely independent of weight loss, with only a third mediated by waist reduction. PICO summary and commentary.

SYNCHRONIZE-1 reports baseline characteristics of a phase 3 survodutide obesity trial; efficacy results are pending. PICO summary and expert commentary.

A SURMOUNT-5 analysis finds tirzepatide and semaglutide improve physical quality of life in obesity, with neither improving mental-health scores. PICO summary and expert commentary.

The phase 2b IMPACT trial finds weekly pemvidutide resolves MASH but does not significantly improve fibrosis at 24 weeks. PICO summary and expert commentary.

Summary: In adults with overweight or obesity following 7-day vancomycin treatment, 2′-fucosyllactose (2′-FL) supplementation for 8 weeks transiently improved gut…

Summary: In adults with type 2 diabetes (n=40), Dibifree dietary phytomix (15 g/day) as add-on therapy significantly reduced HbA1c, fasting/postprandial…