A 12-week trial finds aerobic, Tabata, and HIIT all reduce body fat and circulating hepatokines in obese men, with higher-intensity protocols producing the greatest reductions. PICO summary and commentary.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A first-in-human phase 1 study finds the FGF21 analog zalfermin supports weekly dosing and improves lipids in healthy men. PICO summary and expert commentary.
A 10-week RCT finds plant- and animal-protein calorie-restricted diets both improve metabolic syndrome, with no significant between-group differences except adropin. PICO summary and commentary.
Summary: In young patients with obesity and generalized gingivitis, systemic administration of cerium oxide nanoparticles (Cerera) for 10 days following…
Summary: In adults with obesity and/or type 2 diabetes (mean age 47.9 years, 74% female) referred for physical activity intervention,…
An RCT finds a gamified digital activity programme increases daily steps more than supervised face-to-face exercise in obesity, but with marked individual variability and no clinical-outcome or cost difference. PICO summary and commentary.
Summary: In pregnant women diagnosed with hyperglycemia during pregnancy, a behavioral physical activity intervention promoting unsupervised moderate-intensity walking or stepping…
A 90-day manufacturer-funded RCT finds Cyperus rotundus extract with piperine, added to diet and exercise, reduces weight and central adiposity and improves lipids in obese adults. PICO summary and commentary.
A large RCT finds a nutritionist-designed Mediterranean diet video improves adherence and reduces gestational diabetes from 25.1% to 20.7%, with fewer adverse outcomes. PICO summary and commentary.
A 12-week RCT finds structured yoga improves fasting glucose, HbA1c, and self-care in low-income women with type 2 diabetes, though the glycaemic effect exceeds typical yoga trials. PICO summary and commentary.