Metabolism

Does Tirzepatide Improve Quality of Life More Than Semaglutide in Obesity?

A SURMOUNT-5 analysis finds tirzepatide and semaglutide improve physical quality of life in obesity, with neither improving mental-health scores. PICO summary and expert commentary.

Does Weekly Pemvidutide Resolve MASH Without Worsening Fibrosis?

The phase 2b IMPACT trial finds weekly pemvidutide resolves MASH but does not significantly improve fibrosis at 24 weeks. PICO summary and expert commentary.

Does 2′-Fucosyllactose Supplementation Support Gut Microbiome Recovery After Antibiotic Use?

Can a Hibiscus-Inulin Shot Improve Blood Sugar and Lipid Levels in Overweight Adults?

An 8-week RCT finds a hibiscus-inulin shot produces small reductions in lipid-glucose indices in overweight adults, but the authors stress these reflect analytical responsiveness, not proven clinical benefit. PICO summary and commentary.

Can Walking Help Manage High Blood Sugar During Pregnancy?

A feasibility pilot finds remote walking coaching is acceptable and mitigates late-pregnancy activity decline in pregnancy hyperglycaemia, with only a preliminary suggestion of neonatal benefit. PICO summary and commentary.

Can Interval Training Lower Fat Levels After Meals in Postmenopausal Women?

A small crossover study finds high- and moderate-intensity interval exercise equally reduce post-meal triglycerides in postmenopausal women, with moderate intensity better tolerated. PICO summary and commentary.

Can Exercise and Diet Together Improve Health in Overweight Children?

An RCT finds HIIT combined with a dietitian-designed diet improves body composition, cardiovascular and endothelial function, and lipids more than exercise alone in overweight children. PICO summary and commentary.

Can Healthy Canteen Meals Help Reduce Metabolic Syndrome in Working Men?

An RCT finds healthier canteen lunches plus dietary advice cut metabolic syndrome prevalence by 30.4% in working men, far exceeding health education alone. PICO summary and commentary.

Which Exercise Best Improves Liver Hormones in Obese Men?

A 12-week trial finds aerobic, Tabata, and HIIT all reduce body fat and circulating hepatokines in obese men, with higher-intensity protocols producing the greatest reductions. PICO summary and commentary.

Is Zalfermin Safe and Effective for Weekly Use?

A first-in-human phase 1 study finds the FGF21 analog zalfermin supports weekly dosing and improves lipids in healthy men. PICO summary and expert commentary.