Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A 10-week RCT finds plant- and animal-protein calorie-restricted diets both improve metabolic syndrome, with no significant between-group differences except adropin. PICO summary and commentary.
An RCT finds a gamified digital activity programme increases daily steps more than supervised face-to-face exercise in obesity, but with marked individual variability and no clinical-outcome or cost difference. PICO summary and commentary.
A 90-day manufacturer-funded RCT finds Cyperus rotundus extract with piperine, added to diet and exercise, reduces weight and central adiposity and improves lipids in obese adults. PICO summary and commentary.
A large RCT finds a nutritionist-designed Mediterranean diet video improves adherence and reduces gestational diabetes from 25.1% to 20.7%, with fewer adverse outcomes. PICO summary and commentary.
A 12-week RCT finds structured yoga improves fasting glucose, HbA1c, and self-care in low-income women with type 2 diabetes, though the glycaemic effect exceeds typical yoga trials. PICO summary and commentary.
A 26-week double-blind RCT finds metformin does not reduce insulin resistance in adults with type 1 diabetes, with no change in endogenous glucose production versus placebo. PICO summary and commentary.
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