A 16-week RCT reports two botanical extracts raise GLP-1 and reduce weight comparably to semaglutide, but manufacturer affiliation, implausibly strong correlations, and an unblinded comparator warrant strong caution. PICO summary and commentary.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A small 8-week RCT finds substrate-guided moderate-intensity intermittent walking plus a plant-based diet gives the largest body-fat and fitness improvements in sedentary women; effect sizes should be read cautiously. PICO summary and commentary.
A process evaluation within the PROGROUP feasibility trial finds a 4-day training programme prepares clinicians to deliver group obesity care with moderate fidelity, and was revised toward flexible self-directed learning. PICO summary and commentary.
A 12-week RCT finds gallic acid plus exercise modestly reduces waist circumference, waist-hip ratio, and skinfolds in obesity, with benefits concentrated in the exercise-plus-supplement combination. PICO summary and commentary.
A sham-controlled, blinded RCT finds electroacupuncture modestly reduces BMI and improves metabolic markers and quality of life in obese PCOS, sustained to 24 weeks. PICO summary and commentary.
A secondary analysis of the LeIKD trial finds longer endurance-exercise duration, more than intensity, improves fitness in older patients with coronary heart disease and type 2 diabetes, with early engagement predicting adherence. PICO summary and commentary.
A multicentre RCT finds berberine 1 g/day for 6 months does not reduce visceral or liver fat in obesity with fatty liver disease, though it modestly lowers LDL, apoB, and hs-CRP. PICO summary and commentary.
A small pilot finds 8 days of intranasal vitamin C improves insulin sensitivity and attenuates a brain phosphocreatine decline in men with obesity, without changing food intake. PICO summary and commentary.
A qualitative study finds older adults with metabolic syndrome adhere better to a Mediterranean diet with sustained professional support and family engagement, while limited partner support is a key barrier. PICO summary and commentary.
Summary: In Chinese middle-aged and elderly adults with prediabetes or early diabetes, purified anthocyanin supplementation (160, 320, and 640 mg/day…