An RCT finds combining HIIT with asparagus root extract improves oxidative, inflammatory, and lipid markers in overweight young adults, while the extract alone raises a pro-oxidant marker. PICO summary and commentary.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A 24-week RCT finds neither a low-carbohydrate nor a Mediterranean diet significantly changes bone turnover markers in young people with type 1 diabetes, an exploratory null result. PICO summary and commentary.
Summary: In individuals at risk for dementia with cardiometabolic features, intentional, non-pharmacological weight loss significantly reduced dementia risk as detected…
Summary: In older adults at risk for type 2 diabetes, resistance exercise training significantly improved targeted cognitive function compared to…
Summary: In adults with prediabetes, metformin combined with aerobic exercise significantly improved skeletal muscle tissue characteristics and metabolic markers compared…
A small 12-week MRI trial finds aerobic exercise improves muscle composition and achieves normoglycaemia in 80-90% of prediabetic adults versus 20% with metformin, with combination adding visceral-fat and muscle-size benefit. PICO summary and commentary.
The NAFLDiet trial finds both a low-carb high-PUFA diet and a healthy Nordic diet reduce liver fat versus usual care, but only the Nordic diet also improves weight, HbA1c, triglycerides, and inflammation. PICO summary and commentary.
A small crossover study finds a high-carb diet shifts exercise fuel toward carbohydrate, while low-carb diets give more time in euglycaemia and less hyperglycaemia around fasted exercise in type 1 diabetes. PICO summary and commentary.
A small 4-week RCT finds L-citrulline 6 g/day improves endothelial function, leg arterial stiffness, and glucose in type 2 diabetes, in both fasted and acute-hyperglycaemic states. PICO summary and commentary.
A 12-week RCT finds both combined training and HIIT improve glucose, body composition, and quality of life in type 2 diabetes, with HIIT favouring fasting glucose and combined training favouring insulin resistance and wellbeing. PICO summary and commentary.