Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A multicentre RCT finds berberine 1 g/day for 6 months does not reduce visceral or liver fat in obesity with fatty liver disease, though it modestly lowers LDL, apoB, and hs-CRP. PICO summary and commentary.
A small pilot finds 8 days of intranasal vitamin C improves insulin sensitivity and attenuates a brain phosphocreatine decline in men with obesity, without changing food intake. PICO summary and commentary.
A qualitative study finds older adults with metabolic syndrome adhere better to a Mediterranean diet with sustained professional support and family engagement, while limited partner support is a key barrier. PICO summary and commentary.
A secondary analysis of the Minnesota Green Tea Trial finds high-dose green tea extract does not reduce inflammatory markers in overweight postmenopausal women, a robust null result. PICO summary and commentary.
A 12-week dose-response trial finds purified anthocyanin supplements up to 640 mg/day do not improve arterial stiffness, blood pressure, or cardiovascular risk in older adults with high blood sugar. PICO summary and commentary.
An RCT finds seated exercise gives greater pain relief, knee function, and physical quality of life than standing exercise in obese women with knee osteoarthritis, while standing favours mental quality of life. PICO summary and commentary.
A 6-month open-label RCT finds adding a Mediterranean diet and nutritional supplements to dapagliflozin improves glycaemia, albuminuria, nutrition, and quality of life more than dapagliflozin alone in diabetic nephropathy. PICO summary and commentary.
An RCT finds combining HIIT with asparagus root extract improves oxidative, inflammatory, and lipid markers in overweight young adults, while the extract alone raises a pro-oxidant marker. PICO summary and commentary.
A 24-week RCT finds neither a low-carbohydrate nor a Mediterranean diet significantly changes bone turnover markers in young people with type 1 diabetes, an exploratory null result. PICO summary and commentary.
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