Browsing: Metabolism

A prespecified SELECT analysis finds semaglutide’s cardiovascular benefit is largely independent of weight loss, with only a third mediated by waist reduction. PICO summary and commentary.

SYNCHRONIZE-1 reports baseline characteristics of a phase 3 survodutide obesity trial; efficacy results are pending. PICO summary and expert commentary.

A SURMOUNT-5 analysis finds tirzepatide and semaglutide improve physical quality of life in obesity, with neither improving mental-health scores. PICO summary and expert commentary.

The phase 2b IMPACT trial finds weekly pemvidutide resolves MASH but does not significantly improve fibrosis at 24 weeks. PICO summary and expert commentary.

Summary: In adults with overweight or obesity following 7-day vancomycin treatment, 2′-fucosyllactose (2′-FL) supplementation for 8 weeks transiently improved gut…

An 8-week RCT finds a hibiscus-inulin shot produces small reductions in lipid-glucose indices in overweight adults, but the authors stress these reflect analytical responsiveness, not proven clinical benefit. PICO summary and commentary.

A feasibility pilot finds remote walking coaching is acceptable and mitigates late-pregnancy activity decline in pregnancy hyperglycaemia, with only a preliminary suggestion of neonatal benefit. PICO summary and commentary.

A small crossover study finds high- and moderate-intensity interval exercise equally reduce post-meal triglycerides in postmenopausal women, with moderate intensity better tolerated. PICO summary and commentary.

An RCT finds HIIT combined with a dietitian-designed diet improves body composition, cardiovascular and endothelial function, and lipids more than exercise alone in overweight children. PICO summary and commentary.

An RCT finds healthier canteen lunches plus dietary advice cut metabolic syndrome prevalence by 30.4% in working men, far exceeding health education alone. PICO summary and commentary.