Summary: In individuals at risk for dementia with cardiometabolic features, intentional, non-pharmacological weight loss significantly reduced dementia risk as detected…
Browsing: Obesity & Weight Management
Evidence summaries for obesity and weight management, including lifestyle trials, pharmacotherapy, bariatric/metabolic outcomes, cardiometabolic risk, and long-term safety.
A prespecified SELECT analysis finds semaglutide’s cardiovascular benefit is largely independent of weight loss, with only a third mediated by waist reduction. PICO summary and commentary.
SYNCHRONIZE-1 reports baseline characteristics of a phase 3 survodutide obesity trial; efficacy results are pending. PICO summary and expert commentary.
A SURMOUNT-5 analysis finds tirzepatide and semaglutide improve physical quality of life in obesity, with neither improving mental-health scores. PICO summary and expert commentary.
An RCT finds HIIT combined with a dietitian-designed diet improves body composition, cardiovascular and endothelial function, and lipids more than exercise alone in overweight children. PICO summary and commentary.
Summary: In young patients with obesity and generalized gingivitis, systemic administration of cerium oxide nanoparticles (Cerera) for 10 days following…
Summary: In adults with obesity and/or type 2 diabetes (mean age 47.9 years, 74% female) referred for physical activity intervention,…
An RCT finds a gamified digital activity programme increases daily steps more than supervised face-to-face exercise in obesity, but with marked individual variability and no clinical-outcome or cost difference. PICO summary and commentary.
A 90-day manufacturer-funded RCT finds Cyperus rotundus extract with piperine, added to diet and exercise, reduces weight and central adiposity and improves lipids in obese adults. PICO summary and commentary.
An RCT finds a 12-week school interval jump rope programme improves body composition, fitness, and glucose and lipid markers in overweight adolescents. PICO summary and commentary.