Can PEG-Loxe Help Super-Obese Patients with Type 2 Diabetes Lose Weight?
An RCT finds the weekly GLP-1 agonist PEG-Loxe produces large dose-dependent weight loss in super-obese patients with type 2 diabetes. PICO summary and expert commentary.
Obesity & Weight Management
Evidence summaries for obesity and weight management, including lifestyle trials, pharmacotherapy, bariatric/metabolic outcomes, cardiometabolic risk, and long-term safety.
Does Weight Stigma Trigger Immediate Physical Stress in Women with Obesity?
A feasibility study finds preliminary but non-significant physiological responses to weight stigma in women with obesity, while proving the method workable. PICO summary and commentary.
Can Spinach Extract and Functional Training Improve Obesity-Related Markers in Men?
A four-arm trial finds functional training improves obesity markers in men, with spinach thylakoid supplementation adding little. PICO summary and expert commentary.
Can a Fat-Rich Snack Before a Carb Meal Affect Blood Sugar After Sleeve Gastrectomy?
A proof-of-concept crossover study finds a fat preload does not change postprandial glucose after sleeve gastrectomy, but raises insulin. PICO summary and commentary.
Can CKDB-322 Help Reduce Body Fat in Overweight Adults?
A 12-week double-blind RCT finds a probiotic-microalgae supplement (CKDB-322) reduces body fat, abdominal fat, triglycerides, and leptin in overweight adults; the study was manufacturer-conducted. PICO summary and commentary.
Which Diet Best Boosts Metabolism and Orexin-A in Obesity?
A small 12-month RCT finds a ketogenic diet gives the largest sustained metabolic improvements while 16:8 time-restricted eating most consistently raises orexin-A; the orexin-A findings are exploratory. PICO summary and commentary.
Do Dietary Habits Predict Weight Regain or Maintenance After Weight Loss?
A secondary analysis of Look AHEAD finds adults who regained weight showed greater declines in diet quality over 3 years than maintainers, an associational finding emphasising sustained dietary quality. PICO summary and commentary.
Does a Ketogenic Diet Change Amino Acid Metabolism in Overweight Women?
An 8-week RCT finds a ketogenic diet alters amino acid metabolism in women with overweight, raising branched-chain and α-aminobutyric acids; these are mechanistic biomarker changes, not clinical outcomes. PICO summary and commentary.
Can Ashwagandha Help Reduce Stress and Support Weight Loss?
A 24-week RCT reports ashwagandha root extract reduces weight, BMI, stress, and food cravings versus placebo; the large weight-loss magnitude for an adaptogen supplement warrants cautious interpretation. PICO summary and commentary.
By-Band-Sleeve Trial: Gastric Bypass vs Band vs Sleeve for Severe Obesity
The large UK By-Band-Sleeve RCT finds gastric bypass and sleeve gastrectomy outperform gastric banding for weight loss and quality of life at 3 years, with bypass giving greater weight loss than sleeve and best cost-effectiveness. PICO summary and commentary.