Obesity & Weight Management
Evidence summaries for obesity and weight management, including lifestyle trials, pharmacotherapy, bariatric/metabolic outcomes, cardiometabolic risk, and long-term safety.
“How effective is the combination of orlistat, pioglitazone, and metformin for treating obesity in type 2 diabetes patients?”
A multicentre RCT finds adding orlistat to pioglitazone and metformin improves weight, visceral fat, and insulin sensitivity in obese type 2 diabetes, but not HbA1c. PICO summary and commentary.
MIND Diet Improves Cognition Only in Class II+ Obesity: Subgroup Analysis from Randomized Trial
An analysis of the overall-negative MIND diet trial finds a cognitive benefit only in older adults with BMI 35 or above, a hypothesis-generating subgroup signal. PICO summary and commentary.
Does BMI Affect the Benefits of Bivalirudin Over Heparin in Heart Attack Patients?
A prespecified BRIGHT-4 subgroup analysis finds bivalirudin reduces death or major bleeding versus heparin in lower-BMI STEMI patients but not higher-BMI, with a significant interaction. PICO summary and commentary.
Do Barley Cereals Improve Health in Overweight Adults?
A small 6-week RCT finds barley-based cereal improves weight, glycated albumin, and LDL versus corn cereal in overweight adults. PICO summary and commentary.
