A Lancet phase 2 RCT finds once-weekly semaglutide 2.4 mg reduces heavy drinking days in alcohol use disorder with obesity. PICO summary and expert commentary for clinicians.
Browsing: Obesity & Weight Management
Evidence summaries for obesity and weight management, including lifestyle trials, pharmacotherapy, bariatric/metabolic outcomes, cardiometabolic risk, and long-term safety.
A crossover nutrigenomics trial finds elderberry juice broadens meal-responsive gene expression in overweight adults, but measures no clinical endpoints. PICO summary and commentary.
A cluster RCT finds peer coaching boosts engagement with weight-management services but misses its 12-month weight endpoint. PICO summary and expert commentary for clinicians.
A feasibility pilot finds the Confident Moves online programme engages adults with obesity and nudges activity, but measures no weight outcomes. PICO summary and expert commentary.
An RCT finds fixed-intensity combined training reduces the visceral adiposity index more than progressive training in obesity, without changing metabolic phenotype. PICO summary and commentary.
An RCT finds parent-based lifestyle change reduces BMI in preschoolers, while salivary AMY1 copy number does not predict response. PICO summary and expert commentary.
A 12-month RCT finds curcumin 1500 mg daily reduces liver fat, stiffness, and HbA1c in obese type 2 diabetes with MASLD. PICO summary and expert commentary for clinicians.
The LIFE-Moms analysis finds lifestyle counselling slows but does not reverse the activity decline in pregnant women with obesity. PICO summary and expert commentary.
An RCT finds a culturally tailored South Asian calorie-restriction diet produces modest short-term weight loss in young adults. PICO summary and expert commentary.
A small crossover trial finds whole-body photobiomodulation acutely raises resting energy expenditure in women with obesity, but measures no durable outcomes. PICO summary and commentary.