Evidence summaries for obesity and weight management, including lifestyle trials, pharmacotherapy, bariatric/metabolic outcomes, cardiometabolic risk, and long-term safety.
A crossover nutrigenomics trial finds elderberry juice broadens meal-responsive gene expression in overweight adults, but measures no clinical endpoints. PICO summary and commentary.
A cluster RCT finds peer coaching boosts engagement with weight-management services but misses its 12-month weight endpoint. PICO summary and expert commentary for clinicians.
A feasibility pilot finds the Confident Moves online programme engages adults with obesity and nudges activity, but measures no weight outcomes. PICO summary and expert commentary.
An RCT finds fixed-intensity combined training reduces the visceral adiposity index more than progressive training in obesity, without changing metabolic phenotype. PICO summary and commentary.
An RCT finds parent-based lifestyle change reduces BMI in preschoolers, while salivary AMY1 copy number does not predict response. PICO summary and expert commentary.
A 12-month RCT finds curcumin 1500 mg daily reduces liver fat, stiffness, and HbA1c in obese type 2 diabetes with MASLD. PICO summary and expert commentary for clinicians.
The LIFE-Moms analysis finds lifestyle counselling slows but does not reverse the activity decline in pregnant women with obesity. PICO summary and expert commentary.
An RCT finds a culturally tailored South Asian calorie-restriction diet produces modest short-term weight loss in young adults. PICO summary and expert commentary.
A small crossover trial finds whole-body photobiomodulation acutely raises resting energy expenditure in women with obesity, but measures no durable outcomes. PICO summary and commentary.
The Swedish Obese Subjects (SOS) study demonstrated that bariatric surgery is associated with a 29% reduction in adjusted all-cause mortality compared with conventional obesity treatment over an average 10.9 years of follow-up, with reductions in both cardiovascular and cancer deaths, providing the first prospective controlled evidence for the long-term survival benefit of surgical weight loss.
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