Summary:
In overweight or obese adults without chronic illness, short-term American black elderberry juice (EBJ) supplementation significantly enhanced transcriptional responses to meal intake and enriched pathways regulating metabolic flexibility compared to placebo (PL) beverage during a 5-week crossover trial, though it was associated with no significant adverse effects reported.
| PICO | Description |
|---|---|
| Population | Overweight or obese adults (BMI >25 kg/m²) without chronic illnesses. |
| Intervention | American black elderberry juice (EBJ), consumed twice daily for one week in a randomized, crossover feeding trial. |
| Comparison | Placebo beverage consumed under identical conditions during a separate intervention week, with a washout period in between. |
| Outcome | EBJ consumption led to 234 differentially expressed genes related to the fasted-to-fed transition versus 59 genes for PL. Transcriptomic analysis revealed enhanced enrichment of insulin, FoxO, and PI3K-Akt signaling pathways, with 27 KEGG pathways significantly modulated compared to 7 for PL, reflecting improved metabolic flexibility at the transcriptome level. |
Source: Teets, Christy, et al. “One-Week Elderberry Juice Intervention Promotes Metabolic Flexibility in the Transcriptome of Overweight Adults During a Meal Challenge.” Read article here.
