Summary: In overweight/obese adults diagnosed with prediabetes, concurrent aerobic and resistance training combined with daily supplementation of microencapsulated persimmon-karonda polyphenols…
Browsing: Metabolic Syndrome & Insulin Resistance
Metabolic syndrome, insulin resistance, prediabetes physiology, and cardiometabolic risk.
A small crossover trial finds mulberry leaf and corn silk extracts inhibit digestive enzymes in vitro but do not lower post-meal glucose overall in prediabetes, only in an overweight subgroup. PICO summary and commentary.
Summary: In adults with abdominal obesity and at least one additional feature of metabolic syndrome (n=23), an 8-week isoenergetic diet…
Summary: In middle-aged women diagnosed with prediabetes, vitamin D supplementation according to the study protocol demonstrated significantly improved insulin secretion…
A pragmatic cluster RCT finds an SMS lifestyle intervention for prediabetes does not improve HbA1c versus usual care, illustrating that engagement does not equal efficacy. PICO summary and commentary.
An exploratory sub-study finds inflammatory markers fall with weight loss whether by intermittent fasting or calorie restriction, with no fasting-specific advantage. PICO summary and commentary.
Clinical Context Chronic low-grade inflammation is increasingly recognized as a central driver of metabolic disease progression. In obesity and prediabetes,…
A crossover trial finds a moderate-FODMAP diet plus metformin lowers postprandial glucose and raises GLP-1 in prediabetes, with microbiota shifts. PICO summary and commentary.
A 12-week trial finds chicory-root fibre improves whole-body insulin sensitivity and lowers triglycerides in obesity, with butyrate-producing gut bacteria enriched. PICO summary and commentary.
A 54-patient randomized trial testing intermittent Islamic fasting added to lifestyle modification against lifestyle modification alone in adults with metabolic syndrome, with greater percent-change improvements in weight and metabolic markers in the fasting arm. PICO summary and expert commentary.