Metabolic Syndrome & Insulin Resistance
Metabolic syndrome, insulin resistance, prediabetes physiology, and cardiometabolic risk.
How do Mulberry Leaf and Corn Silk Extracts affect post-meal glucose in prediabetics?
A small crossover trial finds mulberry leaf and corn silk extracts inhibit digestive enzymes in vitro but do not lower post-meal glucose overall in prediabetes, only in an overweight subgroup. PICO summary and commentary.
SMS-Based Digital Intervention Fails to Improve HbA1c in Prediabetes: Lessons from PREDIABETEXT
A pragmatic cluster RCT finds an SMS lifestyle intervention for prediabetes does not improve HbA1c versus usual care, illustrating that engagement does not equal efficacy. PICO summary and commentary.
Intermittent Fasting vs Calorie Restriction: Both Reduce Inflammation Equally in Prediabetes
An exploratory sub-study finds inflammatory markers fall with weight loss whether by intermittent fasting or calorie restriction, with no fasting-specific advantage. PICO summary and commentary.
Can Diet and Metformin Improve Prediabetes?
A crossover trial finds a moderate-FODMAP diet plus metformin lowers postprandial glucose and raises GLP-1 in prediabetes, with microbiota shifts. PICO summary and commentary.
Do Chicory Root Fibers Improve Gut Health and Insulin Sensitivity?
A 12-week trial finds chicory-root fibre improves whole-body insulin sensitivity and lowers triglycerides in obesity, with butyrate-producing gut bacteria enriched. PICO summary and commentary.
Intermittent Islamic Fasting Plus Lifestyle vs Lifestyle Alone in Metabolic Syndrome: A Small RCT
A 54-patient randomized trial testing intermittent Islamic fasting added to lifestyle modification against lifestyle modification alone in adults with metabolic syndrome, with greater percent-change improvements in weight and metabolic markers in the fasting arm. PICO summary and expert commentary.