Browsing: Metabolic Syndrome & Insulin Resistance

A small unblinded trial finds Huayu Tongluo moxibustion improves cognition and insulin resistance in type 2 diabetes, with high placebo potential. PICO summary and commentary.

A clamp-based RCT finds metformin does not reduce hepatic insulin resistance in type 1 diabetes, arguing against its use as an insulin-sensitiser. PICO summary and commentary.

An observational analysis nested in PREDIMED-Plus finds older adults with lower dietary inflammatory potential show greater gut microbiota diversity and distinct profiles, an associational finding. PICO summary and commentary.

A small pilot finds 8 days of intranasal vitamin C improves insulin sensitivity and attenuates a brain phosphocreatine decline in men with obesity, without changing food intake. PICO summary and commentary.

Summary: In adults with prediabetes, metformin combined with aerobic exercise significantly improved skeletal muscle tissue characteristics and metabolic markers compared…

A small 12-week MRI trial finds aerobic exercise improves muscle composition and achieves normoglycaemia in 80-90% of prediabetic adults versus 20% with metformin, with combination adding visceral-fat and muscle-size benefit. PICO summary and commentary.

An RCT finds healthier canteen lunches plus dietary advice cut metabolic syndrome prevalence by 30.4% in working men, far exceeding health education alone. PICO summary and commentary.

A 10-week RCT finds plant- and animal-protein calorie-restricted diets both improve metabolic syndrome, with no significant between-group differences except adropin. PICO summary and commentary.

A 26-week double-blind RCT finds metformin does not reduce insulin resistance in adults with type 1 diabetes, with no change in endogenous glucose production versus placebo. PICO summary and commentary.

Summary: In patients with type 2 diabetes mellitus accompanied by cognitive decline, Huayu Tongluo moxibustion therapy targeting specific acupuncture points…