A double-blind dose-response trial finds red and infrared laser all reduce diabetic foot ulcer size over time but with no significant difference between groups; 8-12 J/cm2 gave more responders. PICO summary and commentary.
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A secondary analysis finds probiotics plus omega-3 improve beta-cell function only marginally versus baseline and not versus placebo when adjusted, though secondary metabolic markers improve. PICO summary and commentary.
A small RCT finds adding a dexamethasone implant to vitrectomy with silicone oil tamponade reduces recurrent membranes and improves vision in proliferative diabetic retinopathy with detachment. PICO summary and commentary.
A single-blind RCT finds pictorial foot-care education substantially improves knowledge and practice scores in people with type 2 diabetes in Karachi slums. PICO summary and commentary.
A combined mouse and clinical study finds the anabolic agent rhPTH(1-34) reverses low bone turnover in type 2 diabetic bone disease and improves bone density more than alendronate. PICO summary and commentary.
A prespecified BRIGHT-4 subgroup analysis finds bivalirudin reduces death or major bleeding versus heparin in lower-BMI STEMI patients but not higher-BMI, with a significant interaction. PICO summary and commentary.
Summary: In patients with diabetic foot ulcers (DFU), topical ozonated olive oil significantly improved wound healing, quality of life, glycemic…
A small mechanistic trial in youth-onset type 2 diabetes finds metformin and liraglutide shift gut bacteria and bile acids; bile-acid metabolites, not microbiota shifts, track with glucose. PICO summary and commentary.
Summary: In adults with type 1 diabetes and suboptimal glycemic control (HbA1c ≥ 7.5%), a Bayesian decision support system (DSS)…
An RCT finds topical ozonated olive oil improves diabetic foot ulcer healing, quality of life, and HbA1c, though lipids and IL-6/TNF-a are unchanged despite the title. PICO summary and commentary.