An RCT finds adding ezetimibe to metformin raises PPAR-gamma and adiponectin expression and improves insulin resistance in diabetic fatty liver disease, though endpoints are surrogate. PICO summary and commentary.
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An early RCT finds weekly Wharton’s jelly stem cell-derived exosomes markedly accelerate diabetic foot ulcer healing versus standard care, though the therapy remains investigational. PICO summary and commentary.
A phase-1 crossover study in healthy Korean volunteers found a fixed-dose enavogliflozin/gemigliptin combination pharmacokinetically equivalent to the separate tablets, with food delaying only the time to peak. PICO summary and expert commentary.
A multicentre RCT finds adding orlistat to pioglitazone and metformin improves weight, visceral fat, and insulin sensitivity in obese type 2 diabetes, but not HbA1c. PICO summary and commentary.
An RCT finds intraoperative dexmedetomidine reduces glucose variability, insulin requirements, and CRP in diabetic off-pump CABG patients, though endpoints are surrogate. PICO summary and commentary.
A phase 2 RCT finds placenta-derived cell therapy (PDA-002) for diabetic foot ulcers works best at the lowest dose and in the peripheral-artery-disease subgroup, a dose- and subgroup-specific signal. PICO summary and commentary.
A crossover RCT finds weekly structured telehealth modestly lowers HbA1c and improves time in range in poorly controlled paediatric type 1 diabetes, without more hypoglycaemia. PICO summary and commentary.
Summary: In adults with persistent and recalcitrant diabetic foot ulcers that failed to heal with conventional treatment, full-thickness decellularized placental…
A pragmatic cluster RCT finds an SMS lifestyle intervention for prediabetes does not improve HbA1c versus usual care, illustrating that engagement does not equal efficacy. PICO summary and commentary.
An exploratory sub-study finds inflammatory markers fall with weight loss whether by intermittent fasting or calorie restriction, with no fasting-specific advantage. PICO summary and commentary.