A 6-month structured anti-inflammatory diet-and-exercise programme in 542 adults with prediabetes delayed diabetes onset but did not lower 8-year incidence. PICO summary and expert commentary.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A small single-centre randomised trial mapped subcutaneous adipose gene-expression changes after six months of lifestyle-induced weight loss in men with metabolic syndrome. PICO summary and expert commentary.
In 22,220 older US adults, daily vitamin D did not significantly reduce incident type 2 diabetes, though a pooled meta-analysis hinted at a modest benefit. PICO summary and expert commentary.
Summary: In 1,145 patients with obesity-related HFpEF (LVEF ≥45%, BMI ≥30 kg/m²) from the pooled STEP-HFpEF trials, semaglutide 2.4 mg…
A small community-based controlled study in northeastern Thailand found a health literacy and self-management education program raised health literacy and exercise behaviour, with no glycaemic outcome reported. PICO summary and expert commentary.
A single-centre Shanghai RCT found a family-support self-management programme raised self-management behaviour scores in type 2 diabetes, while HbA1c and other biochemical markers did not improve significantly. PICO summary and expert commentary.
A secondary analysis of the CORDIOPREV trial reports that a lower baseline neutrophil count is associated with type 2 diabetes remission in patients with coronary heart disease following a Mediterranean diet. PICO summary and expert commentary.
A randomized crossover trial in 75 young adults found acute sucralose raised hypothalamic blood flow and, versus sucrose, increased hunger, with no hunger difference versus water. PICO summary and expert commentary.
Summary: In 70 Iranian women with newly diagnosed PCOS (aged 15–40 years), 330 mg of Salvia officinalis extract daily for…
A 3-month randomised controlled trial found that a 10-hour time-restricted eating window did not alter mitochondrial bioenergetics in blood cells of adults at high type 2 diabetes risk. PICO summary and expert commentary.