A 24-week open-label randomised trial testing pioglitazone plus empagliflozin versus monotherapy for fatty liver in type 2 diabetes. PICO summary and expert commentary.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
An acute randomised trial in 57 sedentary adults with type 2 diabetes found a single HIIT session raised flow-mediated dilation more than moderate continuous exercise, while both lowered post-exercise glucose. PICO summary and expert commentary.
A small 12-week factorial feeding trial in prediabetes found that shifting unsaturated fat intake to lunch rather than dinner improved insulin-sensitivity indices, while the primary postprandial glucose outcome was null. PICO summary and expert commentary.
A small secondary analysis of the EDICT randomised trial reports that initial triple therapy was associated with slower carotid intima-media thickness progression and lower liver fat than sequential add-on therapy at matched glycaemic control. PICO summary and expert commentary.
An exploratory randomised trial of an 880 kcal/day total diet replacement programme in 17 adults with compensated MASLD cirrhosis found safe weight loss and reduced liver fat, but cannot confirm efficacy. PICO summary and expert commentary.
Summary: In a post hoc analysis of three clinical trials spanning the glucose tolerance spectrum, fasting and 1-hour circulating Gremlin…
A 12-week randomized controlled trial found light-to-moderate aerobic walking produced no significant between-group change in bone turnover markers versus inactive controls in postmenopausal osteopenia, with functional gains reported. PICO summary and expert commentary.
A 4-arm randomised trial in older adults with prediabetes found HIIT improved peripheral but not whole-body insulin sensitivity, with walking showing the opposite pattern. PICO summary and expert commentary.
The ROBUST study protocol describes a planned randomized trial of a social network-enhanced lifestyle intervention for obesity in Black and Hispanic adults, with no outcome results yet. PICO summary and expert commentary.
A design, recruitment, and baseline-characteristics report for the PREDIABETEXT cluster randomised trial of a digital diabetes-prevention intervention, with no efficacy outcomes yet reported. PICO summary and expert commentary.