Summary: In a post hoc analysis of three clinical trials spanning the glucose tolerance spectrum, fasting and 1-hour circulating Gremlin…
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A 12-week randomized controlled trial found light-to-moderate aerobic walking produced no significant between-group change in bone turnover markers versus inactive controls in postmenopausal osteopenia, with functional gains reported. PICO summary and expert commentary.
A 4-arm randomised trial in older adults with prediabetes found HIIT improved peripheral but not whole-body insulin sensitivity, with walking showing the opposite pattern. PICO summary and expert commentary.
The ROBUST study protocol describes a planned randomized trial of a social network-enhanced lifestyle intervention for obesity in Black and Hispanic adults, with no outcome results yet. PICO summary and expert commentary.
A design, recruitment, and baseline-characteristics report for the PREDIABETEXT cluster randomised trial of a digital diabetes-prevention intervention, with no efficacy outcomes yet reported. PICO summary and expert commentary.
A 6-month structured anti-inflammatory diet-and-exercise programme in 542 adults with prediabetes delayed diabetes onset but did not lower 8-year incidence. PICO summary and expert commentary.
A small single-centre randomised trial mapped subcutaneous adipose gene-expression changes after six months of lifestyle-induced weight loss in men with metabolic syndrome. PICO summary and expert commentary.
In 22,220 older US adults, daily vitamin D did not significantly reduce incident type 2 diabetes, though a pooled meta-analysis hinted at a modest benefit. PICO summary and expert commentary.
Summary: In 1,145 patients with obesity-related HFpEF (LVEF ≥45%, BMI ≥30 kg/m²) from the pooled STEP-HFpEF trials, semaglutide 2.4 mg…
A small community-based controlled study in northeastern Thailand found a health literacy and self-management education program raised health literacy and exercise behaviour, with no glycaemic outcome reported. PICO summary and expert commentary.