Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A secondary analysis of a gestational-diabetes RCT (122 dyads) found cord-blood lipids, but not maternal lipids after correction, were associated with children's beta-cell function at age 9. PICO summary and expert commentary.
A 93-patient RCT found structured exercise after gastric bypass did not improve the primary 2-hour glucose endpoint but added modest weight and fat-mass loss. PICO summary and expert commentary.
A small randomised trial finding that weight loss reduced IL-1β and MASLD comparably with liraglutide or lifestyle, and that baseline IL-1β predicted the extent of MASLD improvement. PICO summary and expert commentary.
Two acute randomized crossover trials found that neither dietary protein source nor carbohydrate glycaemic index significantly altered postprandial glucose in adults with type 1 diabetes. PICO summary and expert commentary.
The NIGOHealth randomized trial found no effect of a low glycaemic index/slow digesting carbohydrate product on primary maternal glycaemia outcomes in obese pregnant women, with only a small secondary HbA1c difference. PICO summary and expert commentary.
A single-centre Chinese RCT found a mobile health lifestyle programme modestly reduced gestational weight gain and fasting glucose in overweight or obese pregnant women, with no effect on gestational diabetes incidence. PICO summary and expert commentary.
A randomised non-inferiority trial of a low-energy total diet replacement programme in people with type 2 diabetes at high eating-disorder risk: PICO summary and expert commentary.
An exploratory secondary analysis of two Phase 2 trials reports that oral orforglipron lowered blood pressure, LDL cholesterol, triglycerides, ApoB, ApoC3, and hsCRP versus placebo, though no cardiovascular events were measured. PICO summary and expert commentary.
A secondary analysis of the FINGER lifestyle trial found that baseline dysglycaemia, especially OGTT-derived measures, was associated with less favourable cognitive and brain changes, while HbA1c showed mixed results. PICO summary and expert commentary.
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