A small single-blind RCT (n=60) found a family-centered empowerment program raised diabetes acceptance and self-management questionnaire scores versus usual care, with no glycaemic outcomes measured. PICO summary and expert commentary.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A small pilot randomised trial (n=30) testing whether an 8-week integrated intensive exercise protocol improves body composition, functional capacity and quality of life in young adults with obesity versus diet plus brisk walking. PICO summary and expert commentary.
A published BMJ Open study protocol for a planned randomised controlled trial of a COM-B-based exercise intervention in prefrail older adults with diabetes; no efficacy results are reported. PICO summary and expert commentary.
A prespecified secondary analysis of a 12-week randomised trial found time-restricted eating did not change sleep, mood, or quality of life versus usual care in adults with overweight or obesity. PICO summary and expert commentary.
A randomised waitlist-controlled trial of a 10-week whole-food plant-based community programme in a predominantly Maori cohort: weight fell by 3.3 kg versus control, but HbA1c, cholesterol and waist changes were not significant. PICO summary and expert commentary.
Clinical Context GLP-1 receptor agonists produce substantial weight loss, but the mechanisms underlying this effect have been debated. Is weight…
A small 12-week randomized controlled trial in male recreational athletes with type 2 diabetes found that only the combined diet plus exercise arm improved both glycemic and body-composition markers, with small effect sizes. PICO summary and expert commentary.
A secondary analysis of a gestational-diabetes RCT (122 dyads) found cord-blood lipids, but not maternal lipids after correction, were associated with children’s beta-cell function at age 9. PICO summary and expert commentary.
Clinical Context Heart failure with preserved ejection fraction (HFpEF) represents one of the most challenging conditions in cardiovascular medicine. Unlike…
A 93-patient RCT found structured exercise after gastric bypass did not improve the primary 2-hour glucose endpoint but added modest weight and fat-mass loss. PICO summary and expert commentary.