An exploratory secondary analysis of two Phase 2 trials reports that oral orforglipron lowered blood pressure, LDL cholesterol, triglycerides, ApoB, ApoC3, and hsCRP versus placebo, though no cardiovascular events were measured. PICO summary and expert commentary.
Browsing: Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A secondary analysis of the FINGER lifestyle trial found that baseline dysglycaemia, especially OGTT-derived measures, was associated with less favourable cognitive and brain changes, while HbA1c showed mixed results. PICO summary and expert commentary.
A multicentre randomised trial found dapagliflozin 10 mg daily for 48 weeks improved biopsy-confirmed MASH without worsening fibrosis in more patients than placebo. PICO summary and expert commentary.
A secondary analysis of a Swedish RCT links higher engagement with a smartphone dietary-education app to modest dietary improvements, with no significant cardiometabolic marker changes, in adults with type 2 diabetes. PICO summary and expert commentary.
A 602-participant Taiwanese RCT found a single one-hour diabetes Conversation Map session modestly lowered three-month HbA1c, with the benefit mediated by diet rather than exercise. PICO summary and expert commentary.
A Peplau-theory self-care education programme improved self-reported self-care but not total treatment adherence in 102 elderly patients with diabetes. PICO summary and expert commentary.
A 92-patient randomized trial in Taiwan tested whether 6-month health coaching improves eGFR in type 2 diabetes with early-stage CKD. PICO summary and expert commentary.
A small open-label RCT testing whether real-time CGM feedback added to individualized nutrition therapy improves diet and sleep in prediabetes with overweight or obesity. PICO summary and expert commentary.
A 2×2 cluster RCT in 284 adults with type 2 diabetes and overweight or obesity testing whether nudge-based dietary education and tableware lower HbA1c. PICO summary and expert commentary.
A small single-centre randomised trial testing weight-lowering hypoglycaemic agents plus a high-protein diet and moderate exercise against standard care for diabetes remission in adults with obesity. PICO summary and expert commentary.