Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
MIND Diet Improves Cognition Only in Class II+ Obesity: Subgroup Analysis from Randomized Trial
An analysis of the overall-negative MIND diet trial finds a cognitive benefit only in older adults with BMI 35 or above, a hypothesis-generating subgroup signal. PICO summary and commentary.
“How Much Dietary Fiber Do DialBetesPlus Users Consume?”
A secondary analysis finds diabetes app users still average only 17 g/day fibre over a year, below target, with no link to HbA1c, suggesting basic app feedback is not enough. PICO summary and commentary.
How do ‘FenuflakesTM’ affect 24-hour glycemic variability in adults with type 2 diabetes?
A small CGM crossover study finds 30 g/day defatted fenugreek flakes reduces 24-hour glucose excursions and variability in type 2 diabetes. PICO summary and commentary.
Can probiotics with omega-3 PUFAs improve pancreatic beta-cell function in type 2 diabetes?
A secondary analysis finds probiotics plus omega-3 improve beta-cell function only marginally versus baseline and not versus placebo when adjusted, though secondary metabolic markers improve. PICO summary and commentary.
Does BMI Affect the Benefits of Bivalirudin Over Heparin in Heart Attack Patients?
A prespecified BRIGHT-4 subgroup analysis finds bivalirudin reduces death or major bleeding versus heparin in lower-BMI STEMI patients but not higher-BMI, with a significant interaction. PICO summary and commentary.
Can Sanxiao Jiuzhi Gong Improve Blood Sugar and Exercise Confidence in Type 2 Diabetes?
A single-centre RCT reports large glycaemic gains from qigong (Sanxiao Jiuzhi Gong) in type 2 diabetes, but the implausibly large effect size warrants caution. PICO summary and commentary.
High-Dose Vitamin D Before Ultramarathon Attenuates Bone Resorption Response: RCT
A double-blind RCT finds a single high dose of vitamin D before an ultramarathon favourably shifts bone turnover markers, though mega-dosing remains experimental. PICO summary and commentary.