Browsing: Metabolism

An RCT finds combined aerobic and resistance training improves modelled insulin secretion and glucose effectiveness more than either alone in men with type 2 diabetes. PICO summary and commentary.

Summary: In adults diagnosed with type 2 diabetes mellitus enrolled in a randomized controlled trial comparing exercise modalities, combined aerobic…

A 12-month RCT finds daily curcumin reduces liver fat, stiffness, and HbA1c and improves inflammatory and antioxidant markers in obese type 2 diabetes with fatty liver. PICO summary and commentary.

An RCT finds adding ezetimibe to metformin raises PPAR-gamma and adiponectin expression and improves insulin resistance in diabetic fatty liver disease, though endpoints are surrogate. PICO summary and commentary.

A multicentre RCT finds adding orlistat to pioglitazone and metformin improves weight, visceral fat, and insulin sensitivity in obese type 2 diabetes, but not HbA1c. PICO summary and commentary.

A pragmatic cluster RCT finds an SMS lifestyle intervention for prediabetes does not improve HbA1c versus usual care, illustrating that engagement does not equal efficacy. PICO summary and commentary.

An exploratory sub-study finds inflammatory markers fall with weight loss whether by intermittent fasting or calorie restriction, with no fasting-specific advantage. PICO summary and commentary.

Clinical Context Chronic low-grade inflammation is increasingly recognized as a central driver of metabolic disease progression. In obesity and prediabetes,…

An analysis of the overall-negative MIND diet trial finds a cognitive benefit only in older adults with BMI 35 or above, a hypothesis-generating subgroup signal. PICO summary and commentary.

A secondary analysis finds diabetes app users still average only 17 g/day fibre over a year, below target, with no link to HbA1c, suggesting basic app feedback is not enough. PICO summary and commentary.