Metabolism
Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
Combined Aerobic and Resistance Training Best Improves Beta-Cell Function in Type 2 Diabetes
An RCT finds combined aerobic and resistance training improves modelled insulin secretion and glucose effectiveness more than either alone in men with type 2 diabetes. PICO summary and commentary.
Curcumin Supplementation Reduces Liver Fat and Inflammation in Obese Type 2 Diabetes: 12-Month RCT
A 12-month RCT finds daily curcumin reduces liver fat, stiffness, and HbA1c and improves inflammatory and antioxidant markers in obese type 2 diabetes with fatty liver. PICO summary and commentary.
“How do metformin and ezetimibe affect gene expression and health in MAFLD patients with type 2 diabetes?”
An RCT finds adding ezetimibe to metformin raises PPAR-gamma and adiponectin expression and improves insulin resistance in diabetic fatty liver disease, though endpoints are surrogate. PICO summary and commentary.
“How effective is the combination of orlistat, pioglitazone, and metformin for treating obesity in type 2 diabetes patients?”
A multicentre RCT finds adding orlistat to pioglitazone and metformin improves weight, visceral fat, and insulin sensitivity in obese type 2 diabetes, but not HbA1c. PICO summary and commentary.
SMS-Based Digital Intervention Fails to Improve HbA1c in Prediabetes: Lessons from PREDIABETEXT
A pragmatic cluster RCT finds an SMS lifestyle intervention for prediabetes does not improve HbA1c versus usual care, illustrating that engagement does not equal efficacy. PICO summary and commentary.
Intermittent Fasting vs Calorie Restriction: Both Reduce Inflammation Equally in Prediabetes
An exploratory sub-study finds inflammatory markers fall with weight loss whether by intermittent fasting or calorie restriction, with no fasting-specific advantage. PICO summary and commentary.