Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A crossover trial finds honey-sweetened yogurt does not change the primary inflammatory marker in postmenopausal women, with only a single secondary signal. PICO summary and commentary.
A large BMJ trial finds vitamin D before IVF raises blood levels but does not improve live birth rates in women with PCOS. PICO summary and expert commentary.
An RCT finds the weekly GLP-1 agonist PEG-Loxe produces large dose-dependent weight loss in super-obese patients with type 2 diabetes. PICO summary and expert commentary.
A feasibility study finds preliminary but non-significant physiological responses to weight stigma in women with obesity, while proving the method workable. PICO summary and commentary.
A four-arm trial finds functional training improves obesity markers in men, with spinach thylakoid supplementation adding little. PICO summary and expert commentary.
A proof-of-concept crossover study finds a fat preload does not change postprandial glucose after sleeve gastrectomy, but raises insulin. PICO summary and commentary.
A metabolomics study finds low-carb high-fat diets perturb lipid metabolites more than energy restriction in elite athletes. PICO summary and expert commentary.
A 12-week double-blind RCT finds a probiotic-microalgae supplement (CKDB-322) reduces body fat, abdominal fat, triglycerides, and leptin in overweight adults; the study was manufacturer-conducted. PICO summary and commentary.
A small 12-month RCT finds a ketogenic diet gives the largest sustained metabolic improvements while 16:8 time-restricted eating most consistently raises orexin-A; the orexin-A findings are exploratory. PICO summary and commentary.
A secondary analysis of Look AHEAD finds adults who regained weight showed greater declines in diet quality over 3 years than maintainers, an associational finding emphasising sustained dietary quality. PICO summary and commentary.
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