An RCT finds adding oral agents to short-term intensive insulin improves early glucose control and beta-cell measures in new type 2 diabetes, but does not improve 12-month remission rates. PICO summary and commentary.
Browsing: Type 2 Diabetes
Clinical evidence summaries for type 2 diabetes, including glycaemic therapies, cardiovascular outcomes, kidney protection, complications, technology, obesity, and long-term safety.
An RCT finds adding a 2-3 week course of intravenous alprostadil to standard care improves the clinical response rate and lipids in diabetic foot or neuropathy, though the trial was unblinded. PICO summary and commentary.
A cost-minimization analysis finds physician-led medication reviews reduce drug count and inappropriate prescriptions in psychiatric outpatients with diabetes while being cost-neutral. PICO summary and commentary.
Summary: In patients with type 2 diabetes experiencing cognitive decline, dapagliflozin and liraglutide treatment significantly improved neuroprotective outcomes compared to…
Summary: In older adults with type 2 diabetes (T2D) and mild cognitive impairment (MCI), hyperbaric oxygen therapy (HBOT) did not…
An observational ACCORD analysis finds higher weight-adjusted waist index is independently associated with more cardiovascular events, heart failure, and mortality in type 2 diabetes, outperforming BMI. PICO summary and commentary.
Summary: In patients with severe mental disorder and diabetes, physician-led medication reviews significantly reduced the number of prescribed drugs and…
The NAFLDiet trial finds both a low-carb high-PUFA diet and a healthy Nordic diet reduce liver fat versus usual care, but only the Nordic diet also improves weight, HbA1c, triglycerides, and inflammation. PICO summary and commentary.
A small 4-week RCT finds L-citrulline 6 g/day improves endothelial function, leg arterial stiffness, and glucose in type 2 diabetes, in both fasted and acute-hyperglycaemic states. PICO summary and commentary.
A 12-week RCT finds both combined training and HIIT improve glucose, body composition, and quality of life in type 2 diabetes, with HIIT favouring fasting glucose and combined training favouring insulin resistance and wellbeing. PICO summary and commentary.