The Diabetes Control and Complications Trial demonstrated that intensive insulin therapy targeting near-normal blood glucose reduced the risk of developing retinopathy by 76% in primary prevention and slowed progression by 54% in secondary intervention, while also substantially reducing nephropathy and neuropathy, establishing the foundational evidence for tight glycaemic control in type 1 diabetes.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
A double-blind RCT finds vitamin D improves insulin secretion and HOMA-IR but not fasting glucose in women with prediabetes. PICO summary and clinical expert commentary.
An RCT finds Bluetooth glucometers match traditional meters on HbA1c during telehealth insulin titration but cut ED visits. PICO summary and expert commentary for clinicians.
An RCT reports resistance exercise plus metformin improves glycaemic control and sleep quality in elderly type 2 diabetes with sleep disorders. PICO summary and expert commentary.
Summary: In pregnant women diagnosed with gestational diabetes mellitus (GDM), continuous glucose monitoring (CGM) significantly improved glycemic control compared to…
A pilot RCT finds prebiotic inulin enriches SCFA-producing gut bacteria but does not improve HbA1c in Indian children with type 1 diabetes. PICO summary and expert commentary.
An RCT finds adding a ketogenic diet to dulaglutide improves glucose, lipids, and insulin resistance in type 2 diabetes. PICO summary and clinical expert commentary.
An RCT finds a short metformin course after antenatal betamethasone lowers maternal glucose and halves neonatal hypoglycaemia. PICO summary and expert commentary for clinicians.
An RCT finds low-carb and Mediterranean diets do not significantly alter bone turnover markers in young people with type 1 diabetes. PICO summary and expert commentary.
An RCT finds an intravitreal dexamethasone implant during diabetic vitrectomy cuts reproliferation and improves vision. PICO summary and expert commentary for clinicians.