Can Sitagliptin Help Heal Diabetic Foot Ulcers?
An RCT finds adding sitagliptin to standard care improves diabetic foot ulcer healing via an EPC/SDF-1α mechanism. PICO summary and expert commentary for clinicians.
Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
Can Aquatic Exercise Improve Blood Pressure and Fitness in People with Type 2 Diabetes?
An RCT finds five weeks of aquatic exercise improves blood pressure and fitness within-group in type 2 diabetes, but shows no advantage over control. PICO summary and commentary.
Can Dexmedetomidine Help Control Blood Sugar During Surgery in Type 2 Diabetes?
An RCT finds low-dose dexmedetomidine steadies perioperative glucose in diabetic surgery while higher doses worsen it. PICO summary and expert commentary for clinicians.
Can 660 nm laser therapy help heal diabetic foot ulcers?
An RCT finds 660 nm photobiomodulation reduces diabetic foot ulcer area but does not beat 904 nm; ≥8 J/cm² works best. PICO summary and expert commentary for clinicians.
Can Family-Based Team Care Improve Outcomes in Hypertension and Diabetes?
An RCT finds interdisciplinary care with family empowerment improves blood pressure, glucose, and quality of life in comorbid hypertension and diabetes. PICO summary and commentary.
Is rhPTH(1-34) More Effective Than Alendronate for Bone Loss in Type 2 Diabetes?
A translational study finds rhPTH(1-34) outperforms alendronate for bone density in diabetic osteoporosis, a low-turnover state. PICO summary and expert commentary for clinicians.
Can Curcumin Improve Fatty Liver in Obese Patients with Type 2 Diabetes?
A 12-month RCT finds curcumin 1500 mg daily reduces liver fat, stiffness, and HbA1c in obese type 2 diabetes with MASLD. PICO summary and expert commentary for clinicians.
Can Probiotics and Omega-3 Improve Beta-Cell Function in Type 2 Diabetes?
An RCT secondary analysis finds probiotics plus omega-3 do not significantly improve beta-cell function versus placebo in type 2 diabetes. PICO summary and expert commentary.
Does Pictorial Foot Care Education Improve Diabetes Outcomes in Karachi Slums?
An RCT finds pictorial foot-care education improves knowledge and self-care in an underserved diabetic population, without measuring ulcers. PICO summary and expert commentary.
Does Sitagliptin Help Protect Bone Health in Women with Type 2 Diabetes?
The SLowDOWN phase III RCT finds sitagliptin preserves hip bone density in women with type 2 diabetes. PICO summary and expert commentary for clinicians.