A 93-patient RCT found structured exercise after gastric bypass did not improve the primary 2-hour glucose endpoint but added modest weight and fat-mass loss. PICO summary and expert commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
Two acute randomized crossover trials found that neither dietary protein source nor carbohydrate glycaemic index significantly altered postprandial glucose in adults with type 1 diabetes. PICO summary and expert commentary.
The NIGOHealth randomized trial found no effect of a low glycaemic index/slow digesting carbohydrate product on primary maternal glycaemia outcomes in obese pregnant women, with only a small secondary HbA1c difference. PICO summary and expert commentary.
A single-centre Chinese RCT found a mobile health lifestyle programme modestly reduced gestational weight gain and fasting glucose in overweight or obese pregnant women, with no effect on gestational diabetes incidence. PICO summary and expert commentary.
A randomised non-inferiority trial of a low-energy total diet replacement programme in people with type 2 diabetes at high eating-disorder risk: PICO summary and expert commentary.
An observational comparison of 76 Colorado primary care practices found that having a diabetes care and education specialist was strongly associated with choosing self-paced CGM implementation over a virtual referral service. PICO summary and expert commentary.
A published protocol for the D-REM pragmatic randomized trial testing community paramedic home visits versus usual care in adults with diabetes and level 3 hypoglycemia. No outcomes are reported yet. PICO summary and expert commentary.
An exploratory secondary analysis of two Phase 2 trials reports that oral orforglipron lowered blood pressure, LDL cholesterol, triglycerides, ApoB, ApoC3, and hsCRP versus placebo, though no cardiovascular events were measured. PICO summary and expert commentary.
A nested qualitative process evaluation of the SuMMiT-D SMS intervention found patients described holistic, context-dependent benefits rather than measured adherence gains. PICO summary and expert commentary.
A secondary analysis of the FINGER lifestyle trial found that baseline dysglycaemia, especially OGTT-derived measures, was associated with less favourable cognitive and brain changes, while HbA1c showed mixed results. PICO summary and expert commentary.