Diabetes

Multifactorial Care vs Standard Care in Type 2 Diabetes: A Randomised Trial

A single-centre randomised trial testing team-delivered multifactorial care against standard care in type 2 diabetes, with modest gains in HbA1c, eGFR and blood pressure control. PICO summary and expert commentary.

Can Stem Cells Plus Shock Wave Therapy Treat Diabetic Erectile Dysfunction?

A small three-arm trial finds stem cells plus shock wave therapy outperform either alone for diabetic erectile dysfunction, a proof-of-concept result. PICO summary and commentary.

Canagliflozin May Increase Thromboembolic Risk in Males With Erythrocytosis: CANVAS Post-Hoc Analysis

Do SGLT2 Inhibitors Reduce Myocardial Fibrosis in Diabetic HFpEF?

A double-blind randomised trial of dapagliflozin versus placebo for myocardial fibrosis on cardiac MRI in 100 patients with type 2 diabetes and HFpEF. PICO summary and expert commentary.

Exenatide Plus Glucagon Co-Infusion Increases Myocardial Glucose Uptake and Improves Diastolic Function in Type 2 Diabetes

A small mechanistic study finds exenatide plus glucagon doubles myocardial glucose uptake in type 2 diabetes, a proof-of-concept for cardiac metabolic effects. PICO summary and commentary.

Ebenatide (PEGylated Exenatide) Improves Glycemic Control, Time in Range, and Body Composition in Type 2 Diabetes

An RCT finds the GLP-1 analogue Ebenatide improves glycaemia, time in range, and body composition in type 2 diabetes, confirming a class effect. PICO summary and commentary.

Does Personalized Care and Glucose Monitoring Improve Diabetes in Pregnancy?

A small single-centre RCT testing CGM-guided individualised care versus self-monitored blood glucose in 80 pregnant women with diabetes. PICO summary and expert commentary.

Does Acute Exenatide-Glucagon Co-Infusion Raise Myocardial Glucose Uptake in Type 2 Diabetes?

An acute crossover infusion study (n=8) found exenatide-glucagon co-infusion raised myocardial glucose uptake and a diastolic strain rate marker in type 2 diabetes. PICO summary and expert commentary.

Pharmacist-Led Care and Quality of Life in Diabetes: An Open-Label RCT

An open-label randomised trial testing pharmacist-led collaborative care against usual care on EQ-5D quality of life and HbA1c in 400 patients with diabetes. PICO summary and expert commentary.

Family-Centered Empowerment Improves Acceptance and Self-Management Scores in Type 2 Diabetes (Small RCT)

A small single-blind RCT (n=60) found a family-centered empowerment program raised diabetes acceptance and self-management questionnaire scores versus usual care, with no glycaemic outcomes measured. PICO summary and expert commentary.