A non-inferiority trial finds once-daily prolonged-release pregabalin relieves diabetic nerve pain as well as immediate-release, offering simpler dosing. PICO summary and commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
A triple-blind RCT finds cinnamon supplementation does not significantly reduce weight or BMI in type 2 diabetes. PICO summary and expert commentary.
A small RCT finds hyaluronic acid adds no periodontal benefit over mechanical cleaning in diabetic periodontitis, though HbA1c fell only in the HA group. PICO summary and commentary.
A four-arm trial finds combination aerobic-resistance exercise is the only programme to improve objective sleep in type 2 diabetes, alongside abdominal fat loss. PICO summary and commentary.
A crossover trial finds almond milk offers no glycaemic advantage over carbohydrate-matched cow milk in type 2 diabetes. PICO summary and expert commentary.
A small 52-week single-centre randomised trial found once-weekly semaglutide shifted lipoprotein subfractions toward a less atherogenic profile versus sitagliptin in type 2 diabetes. PICO summary and expert commentary.
A double-blind RCT finds wound-blotting-guided biofilm management improves the DMIST wound score and biofilm removal in diabetic foot ulcers. PICO summary and commentary.
A single-centre randomised trial testing team-delivered multifactorial care against standard care in type 2 diabetes, with modest gains in HbA1c, eGFR and blood pressure control. PICO summary and expert commentary.
A small three-arm trial finds stem cells plus shock wave therapy outperform either alone for diabetic erectile dysfunction, a proof-of-concept result. PICO summary and commentary.
Clinical Context SGLT2 inhibitors like canagliflozin are cornerstone medications for type 2 diabetes, providing glycemic control alongside cardiovascular and renal…