Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
Tirzepatide Preserves Glucagon Response to Hypoglycemia But Blunts Symptom Awareness: Clamp Study
A clamp study finds tirzepatide preserves the glucagon defence against hypoglycaemia but delays cortisol/noradrenaline and lowers symptom scores, while awareness is unchanged. PICO summary and commentary.
High-Fiber Cereal Improves Liver Fibrosis and Glycemic Control in T2DM with MASLD
An open-label RCT finds 24 g/day fibre cereal improves the FIB-4 fibrosis index and HbA1c in type 2 diabetes with fatty liver, without weight change. PICO summary and commentary.
Does Aquatic Exercise Improve Health in Type 2 Diabetes?
A 5-week RCT finds aquatic exercise improves blood pressure and function within-group in type 2 diabetes, but without significant differences versus controls. PICO summary and commentary.
Can Tai Chi Improve Brain Function in Older Adults With Diabetes?
Editor's note: the source article has been retracted and its findings are not reliable. This page is retained for transparency only and should not guide clinical decisions.
Does Sitagliptin Help Heal Diabetic Foot Ulcers?
An open-label RCT finds adding sitagliptin to standard care improves diabetic foot ulcer healing and raises endothelial progenitor cells, though healing time only trended shorter. PICO summary and commentary.
Does Poorly Controlled Type 1 Diabetes Affect Teen Bone Health?
A 12-month study finds adolescents with poorly controlled type 1 diabetes have low bone density, but glycaemic change does not correlate with bone, while IGF-1 does. PICO summary and commentary.
Can Moxibustion Help Memory in Type 2 Diabetes?
An RCT finds higher-temperature (44-46C) moxibustion improves cognition and HbA1c more than lower temperatures in type 2 diabetes, though fasting glucose was unchanged. PICO summary and commentary.
Exercise Plus Broccoli Sprouts Improves Atherogenic Lipoproteins in Type 2 Diabetes: 12-Week RCT
A four-arm RCT finds exercise plus broccoli sprouts improves apolipoproteins in men with type 2 diabetes, but the benefit is mainly exercise-driven. PICO summary and commentary.