A small RCT finds adding a dexamethasone implant to vitrectomy with silicone oil tamponade reduces recurrent membranes and improves vision in proliferative diabetic retinopathy with detachment. PICO summary and commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
A single-blind RCT finds pictorial foot-care education substantially improves knowledge and practice scores in people with type 2 diabetes in Karachi slums. PICO summary and commentary.
A combined mouse and clinical study finds the anabolic agent rhPTH(1-34) reverses low bone turnover in type 2 diabetic bone disease and improves bone density more than alendronate. PICO summary and commentary.
Summary: In patients with diabetic foot ulcers (DFU), topical ozonated olive oil significantly improved wound healing, quality of life, glycemic…
A small mechanistic trial in youth-onset type 2 diabetes finds metformin and liraglutide shift gut bacteria and bile acids; bile-acid metabolites, not microbiota shifts, track with glucose. PICO summary and commentary.
Summary: In adults with type 1 diabetes and suboptimal glycemic control (HbA1c ≥ 7.5%), a Bayesian decision support system (DSS)…
An RCT finds topical ozonated olive oil improves diabetic foot ulcer healing, quality of life, and HbA1c, though lipids and IL-6/TNF-a are unchanged despite the title. PICO summary and commentary.
A multicentre RCT finds borate bioactive glass fibre matrix doubles 12-week healing of superficial diabetic foot ulcers versus standard care. PICO summary and commentary.
A four-arm RCT finds only low-dose dexmedetomidine improves perioperative glucose in type 2 diabetes, while higher doses raise it, showing a dose-dependent effect. PICO summary and commentary.
Summary: In patients with suboptimal glycemic control, an eHealth application module significantly improved glycemic control compared to usual care without…