A sham-controlled trial finds adding tibial nerve neurodynamic techniques to standard care reduces neuropathy severity and improves quality of life in diabetic neuropathy, though nerve conduction is unchanged. PICO summary and commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
A small RCT finds adding sitagliptin or bedtime NPH insulin lowers HbA1c similarly in type 2 diabetes but produces distinct microRNA changes, with sitagliptin affecting a broader set. PICO summary and commentary.
Summary: In adults with Stage II, Grade B periodontitis and type 2 diabetes mellitus, adjunctive local application of hyaluronan-minocycline gel…
Summary: In young children with Type 1 diabetes mellitus treated with multiple daily insulin injections (MDI), bedtime snacking prior to…
An RCT finds vonoprazan reduces albuminuria and improves eGFR more than lansoprazole in diabetic kidney disease, independent of H. pylori status, suggesting a possible direct renal effect. PICO summary and commentary.
A 20-week RCT finds adding empagliflozin improves glucose, kidney function, neuropathy symptoms, and nerve conduction velocity in type 2 diabetes, though amplitude and exam scores were unchanged. PICO summary and commentary.
A 12-week RCT finds adding sitagliptin to metformin improves fasting glucose, lipids, beta-cell function, and inflammatory cytokines, though HbA1c did not change significantly. PICO summary and commentary.
A subgroup analysis finds adding Control-IQ+ automated insulin delivery to GLP-1 agonist therapy lowers HbA1c and improves time in range without weight gain in insulin-treated type 2 diabetes. PICO summary and commentary.
Summary: In patients with type 2 diabetes mellitus accompanied by cognitive decline, Huayu Tongluo moxibustion therapy targeting specific acupuncture points…
A single-blind RCT finds personalised exercise prescribed from the Chester Step Test reduces glycaemic variability in type 2 diabetes under free-living conditions. PICO summary and commentary.