A small open-label RCT finds early NPH insulin plus infusion speeds resolution of severe DKA and delays rebound hyperglycaemia, without a significant difference in hypoglycaemia. PICO summary and commentary.
Browsing: Diabetes
Evidence summaries and landmark trials across type 1, type 2, prevention, glycaemic control, complications, and diabetes technology.
Clinical Context Gestational diabetes mellitus (GDM) affects 6-9% of pregnancies globally and is associated with significant maternal and fetal complications.…
Summary: In patients with type 2 diabetes mellitus enrolled in a community residency training program, a three-tiered linkage management model…
A 3-month MOBILE analysis finds CGM lowers HbA1c more than fingerstick monitoring and reduces hypoglycaemia in basal-insulin-treated type 2 diabetes, with benefits within a week. PICO summary and commentary.
A crossover trial finds two extended-bolus algorithms both control post-meal glucose in adolescent type 1 diabetes; the simpler Sieradzki method trends better but not significantly. PICO summary and commentary.
A small pilot finds a fully closed-loop insulin-pramlintide system without carb counting achieves time in range similar to carb-counted control, with a non-significant hypoglycaemia signal. PICO summary and commentary.
Summary: In adults with type 1 diabetes requiring insulin therapy, a fully closed-loop system combining automated insulin and pramlintide delivery…
A crossover CGM study in healthy young women finds eating vegetables and protein before carbohydrates, in five smaller meals, reduces glucose variability and peaks. PICO summary and commentary.
Summary: In adult patients with diabetic foot ulcers requiring wound closure, application of polylactic acid (PLA) dermal matrix dressings demonstrated…
Summary: In pregnant women diagnosed with gestational diabetes mellitus from both culturally and linguistically diverse (CALD) and non-CALD backgrounds, a…