Microvascular and macrovascular complications of diabetes: retinopathy, nephropathy, neuropathy, and cardiovascular risk.
An RCT finds pictorial foot-care education improves knowledge and self-care in an underserved diabetic population, without measuring ulcers. PICO summary and expert commentary.
An RCT reports topical Wharton's jelly stem cell exosomes dramatically speed diabetic foot ulcer healing, though the control healing time invites caution. PICO summary and expert commentary.
DAPA-CKD demonstrated that dapagliflozin reduced the composite of a sustained 50% or greater eGFR decline, end-stage kidney disease, or renal or cardiovascular death by 39% in patients with albuminuric CKD with or without type 2 diabetes, extending nephroprotective SGLT2 inhibition beyond diabetic nephropathy to a broad CKD population for the first time.
A 20-week RCT finds empagliflozin improves nerve conduction velocity in diabetic neuropathy but not clinical exam scores, with glycaemic confounding. PICO summary and commentary.
A sham-controlled trial finds tibial nerve neurodynamic techniques improve neuropathy severity and quality of life in diabetic neuropathy, without changing nerve conduction. PICO summary and commentary.
The FINE-ONE NEJM trial finds finerenone reduces albuminuria in type 1 diabetes and CKD, a surrogate-based extension of its type 2 benefits. PICO summary and commentary.
A small crossover trial finds a BCAA, HMB, and zinc supplement increases muscle mass and lowers inflammation in dialysis patients, but not physical performance. PICO summary and commentary.
An RCT finds pentoxifylline reduces microalbuminuria, preserves eGFR, and improves left ventricular mass index over 12 months in advanced diabetic nephropathy, using surrogate endpoints. PICO summary and commentary.
An RCT finds ILM peeling during vitrectomy for proliferative diabetic retinopathy reduces epiretinal membrane formation and repeat anti-VEGF injections, but does not improve visual acuity. PICO summary and commentary.
A combined clinical and mechanistic study finds a TCM formula (Suyin Detoxification Prescription) reduces creatinine and proteinuria in diabetic nephropathy via an FXR pathway, though clinical evidence remains preliminary. PICO summary and commentary.
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