Microvascular and macrovascular complications of diabetes: retinopathy, nephropathy, neuropathy, and cardiovascular risk.
A sham-controlled trial finds adding tibial nerve neurodynamic techniques to standard care reduces neuropathy severity and improves quality of life in diabetic neuropathy, though nerve conduction is unchanged. PICO summary and commentary.
An RCT finds vonoprazan reduces albuminuria and improves eGFR more than lansoprazole in diabetic kidney disease, independent of H. pylori status, suggesting a possible direct renal effect. PICO summary and commentary.
A 20-week RCT finds adding empagliflozin improves glucose, kidney function, neuropathy symptoms, and nerve conduction velocity in type 2 diabetes, though amplitude and exam scores were unchanged. PICO summary and commentary.
An ASCOT analysis finds high blood pressure variability is strongly linked to worse cardiovascular and renal outcomes in diabetes, with amlodipine-based therapy reducing events partly via lower variability. PICO summary and commentary.
A 6-month RCT finds calcitriol lowers inflammation and tubular-injury biomarkers in early diabetic kidney disease, but the albuminuria reduction was not statistically significant. PICO summary and commentary.
An early RCT finds weekly Wharton's jelly stem cell-derived exosomes markedly accelerate diabetic foot ulcer healing versus standard care, though the therapy remains investigational. PICO summary and commentary.
A phase 2 RCT finds placenta-derived cell therapy (PDA-002) for diabetic foot ulcers works best at the lowest dose and in the peripheral-artery-disease subgroup, a dose- and subgroup-specific signal. PICO summary and commentary.
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