Hormone Insight Editorial Team
Clinical archive
Can Exercise and Metformin Improve Muscle Health in Prediabetes?
A small 12-week MRI trial finds aerobic exercise improves muscle composition and achieves normoglycaemia in 80-90% of prediabetic adults versus 20% with metformin, with combination adding visceral-fat and muscle-size benefit. PICO summary and commentary.
Can SGLT2 Inhibitors Reduce Eye Injection Needs in Diabetic Patients with High Blood Pressure?
A small post hoc COMET subgroup finds SGLT2 inhibitor use is associated with about half as many eye injections in diabetic macular edema with high blood pressure, an exploratory finding from 29 patients. PICO summary and commentary.
Can Home-Based Education Improve Diabetes Self-Management?
A small RCT finds home-based diabetes self-management education using Orem's self-care model improves glucose, HbA1c, lipids, blood pressure, and self-care over six weeks. PICO summary and commentary.
How does weight-adjusted waist index predict cardiovascular outcomes in type 2 diabetes?
An observational ACCORD analysis finds higher weight-adjusted waist index is independently associated with more cardiovascular events, heart failure, and mortality in type 2 diabetes, outperforming BMI. PICO summary and commentary.
How do Tirzepatide and Dulaglutide compare for cardiovascular outcomes in Type 2 Diabetes?
The SURPASS-CVOT trial finds tirzepatide noninferior but not superior to dulaglutide for major cardiovascular events in type 2 diabetes, confirming both incretin therapies are cardioprotective. PICO summary and commentary.