Is Zalfermin Safe and Effective for Weekly Use?
A first-in-human phase 1 study finds the FGF21 analog zalfermin supports weekly dosing and improves lipids in healthy men. PICO summary and expert commentary.
Hormone Insight Editorial Team
Clinical archive
Can Replacing Some Animal Protein with Plant Protein Improve Metabolic Health?
A 10-week RCT finds plant- and animal-protein calorie-restricted diets both improve metabolic syndrome, with no significant between-group differences except adropin. PICO summary and commentary.
Telemedicine Home Care for Diabetic Foot Ulcers: Comparable Healing, Better Self-Management
An RCT finds telemedicine-based home care achieves wound healing comparable to in-person care for diabetic foot ulcers, with no significant difference in healing but better self-management. PICO summary and commentary.
How Does the VISTA Phase III Trial Assess Ellipsoid Zone Integrity and Fluid Dynamics?
A machine-learning analysis of the VISTA trial finds aflibercept better preserves photoreceptor ellipsoid-zone integrity and reduces retinal fluid than laser in diabetic macular edema, with structure correlating with vision. PICO summary and commentary.
How Does Finerenone Affect Arterial Stiffness in Diabetes and Kidney Disease?
The FIVE-STAR mechanistic trial finds finerenone does not change arterial stiffness but reduces albuminuria in diabetic kidney disease, pointing to an intraglomerular-pressure mechanism. PICO summary and commentary.
Cryopreserved Amniotic Membrane for Complex Diabetic Foot Ulcers: Multi-Center RCT Results
A multicentre RCT finds adding cryopreserved amniotic membrane to standard care does not significantly improve healing in complex diabetic foot ulcers, though both arms healed well and it was safe. PICO summary and commentary.
Can Gamified Digital Health Programs Improve Obesity Management?
An RCT finds a gamified digital activity programme increases daily steps more than supervised face-to-face exercise in obesity, but with marked individual variability and no clinical-outcome or cost difference. PICO summary and commentary.