Hormone Insight Editorial Team
Clinical archive
Low-Carb High-PUFA vs Healthy Nordic Diet for Liver Fat in Type 2 Diabetes (NAFLDiet)
The NAFLDiet trial finds both a low-carb high-PUFA diet and a healthy Nordic diet reduce liver fat versus usual care, but only the Nordic diet also improves weight, HbA1c, triglycerides, and inflammation. PICO summary and commentary.
Is Combining Metformin and Liraglutide Effective for PCOS and Gut Health?
An open-label RCT finds combining metformin and liraglutide reduces weight, visceral fat, and free testosterone more than metformin alone in PCOS, with a rat study suggesting a gut-microbiota mechanism. PICO summary and commentary.
How Diet Macronutrient Composition Affects Exercise Metabolism in Type 1 Diabetes
A small crossover study finds a high-carb diet shifts exercise fuel toward carbohydrate, while low-carb diets give more time in euglycaemia and less hyperglycaemia around fasted exercise in type 1 diabetes. PICO summary and commentary.
How does L-Citrulline affect vascular health and blood sugar in older adults with type 2 diabetes?
A small 4-week RCT finds L-citrulline 6 g/day improves endothelial function, leg arterial stiffness, and glucose in type 2 diabetes, in both fasted and acute-hyperglycaemic states. PICO summary and commentary.
Which training method is better for type 2 diabetes: combined aerobic and resistance training or high-intensity interval training?
A 12-week RCT finds both combined training and HIIT improve glucose, body composition, and quality of life in type 2 diabetes, with HIIT favouring fasting glucose and combined training favouring insulin resistance and wellbeing. PICO summary and commentary.
How do Vyntus CPX and Vmax Encore 29N compare for indirect calorimetry in type 2 diabetes?
A small crossover validation study finds the Vyntus CPX metabolic cart gives indirect-calorimetry measurements comparable to the Vmax Encore 29N in type 2 diabetes, with only minor differences. PICO summary and commentary.
How Does Gestational Diabetes Affect Maternal and Offspring Health Three Years Later?
A secondary analysis finds women with gestational diabetes reach similar BMI to unaffected women by 3 years postpartum, but their children are twice as likely to be overweight despite comparable diets. PICO summary and commentary.
Does Semaglutide’s Cardiovascular Benefit Depend on Weight Loss in the SELECT Trial?
A prespecified SELECT analysis finds semaglutide's cardiovascular benefit is largely independent of weight loss, with only a third mediated by waist reduction. PICO summary and commentary.
What Are the Baseline Characteristics of the Survodutide SYNCHRONIZE-1 Obesity Trial?
SYNCHRONIZE-1 reports baseline characteristics of a phase 3 survodutide obesity trial; efficacy results are pending. PICO summary and expert commentary.