A small crossover validation study finds the Vyntus CPX metabolic cart gives indirect-calorimetry measurements comparable to the Vmax Encore 29N in type 2 diabetes, with only minor differences. PICO summary and commentary.
A secondary analysis finds women with gestational diabetes reach similar BMI to unaffected women by 3 years postpartum, but their children are twice as likely to be overweight despite comparable diets. PICO summary and commentary.
A prespecified SELECT analysis finds semaglutide's cardiovascular benefit is largely independent of weight loss, with only a third mediated by waist reduction. PICO summary and commentary.
SYNCHRONIZE-1 reports baseline characteristics of a phase 3 survodutide obesity trial; efficacy results are pending. PICO summary and expert commentary.
A SURMOUNT-5 analysis finds tirzepatide and semaglutide improve physical quality of life in obesity, with neither improving mental-health scores. PICO summary and expert commentary.
The phase 2b IMPACT trial finds weekly pemvidutide resolves MASH but does not significantly improve fibrosis at 24 weeks. PICO summary and expert commentary.
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