Obesity and weight management, metabolic syndrome and insulin resistance, MASLD/fatty liver, and nutrition and lifestyle evidence.
A Lancet phase 2 RCT finds once-weekly semaglutide 2.4 mg reduces heavy drinking days in alcohol use disorder with obesity. PICO summary and expert commentary for clinicians.
An RCT finds a structured lifestyle-based programme improves health behaviours and beliefs in type 2 diabetes, though without glycaemic endpoints. PICO summary and expert commentary.
A crossover nutrigenomics trial finds elderberry juice broadens meal-responsive gene expression in overweight adults, but measures no clinical endpoints. PICO summary and commentary.
A cluster RCT finds peer coaching boosts engagement with weight-management services but misses its 12-month weight endpoint. PICO summary and expert commentary for clinicians.
An RCT finds adding Tai Chi to time-restricted eating improves lipids and endothelial function in postmenopausal women. PICO summary and expert commentary for clinicians.
An RCT finds combining exercise with broccoli sprout supplementation improves apolipoproteins in type 2 diabetes, mainly driven by exercise. PICO summary and expert commentary.
A feasibility pilot finds the Confident Moves online programme engages adults with obesity and nudges activity, but measures no weight outcomes. PICO summary and expert commentary.
An RCT finds five weeks of aquatic exercise improves blood pressure and fitness within-group in type 2 diabetes, but shows no advantage over control. PICO summary and commentary.
An RCT finds fixed-intensity combined training reduces the visceral adiposity index more than progressive training in obesity, without changing metabolic phenotype. PICO summary and commentary.
An RCT finds parent-based lifestyle change reduces BMI in preschoolers, while salivary AMY1 copy number does not predict response. PICO summary and expert commentary.
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