A small pilot finds curcumin lowers HbA1c in prediabetic older adults, but without changing weight, lipids, or overall gut microbiome diversity. PICO summary and commentary.
Browsing: Metabolic Syndrome & Insulin Resistance
Metabolic syndrome, insulin resistance, prediabetes physiology, and cardiometabolic risk.
An ACCORD analysis finds a triglyceride-glucose-waist index independently predicts cardiovascular events and mortality in type 2 diabetes, beating TyG alone. PICO summary and commentary.
In a phase 2 trial, the antisense DGAT2 inhibitor ION224 met the primary histological endpoint in MASH with fibrosis at week 51, though benefit remains preliminary and per-protocol. PICO summary and expert commentary.
A post-hoc analysis finds exenatide does not change inflammatory or metabolic biomarkers in alcohol use disorder, despite raised baseline inflammation. PICO summary and commentary.
A secondary analysis of a metformin-versus-insulin gestational diabetes trial found cord serum lipids associated with offspring beta-cell function at age nine. PICO summary and expert commentary.
A LIFE-Moms secondary analysis finds maternal metabolic phenotype drives gestational diabetes and infant adiposity beyond weight gain, with similar treatment response. PICO summary and commentary.
An RCT finds reducing sitting did not help metabolic flexibility overall, but those cutting at least 30 minutes a day of sitting improved it. PICO summary and commentary.
Clinical Context Sedentary behavior—prolonged sitting or reclining with minimal energy expenditure—has emerged as an independent risk factor for cardiometabolic disease,…
A 50-year follow-up of the Auckland Steroid Trial finds no transgenerational metabolic harm in the grandchildren of antenatal-steroid pregnancies. PICO summary and commentary.
A single-centre Egyptian RCT testing whether adding Islamic intermittent fasting to lifestyle modification improves metabolic syndrome markers, with PICO summary and expert commentary.