Landmark Trials in Endocrinology & Metabolism
Practice-changing trialsPractice-changing landmark trials in endocrinology and metabolism, organized for rapid clinical review, exam preparation, teaching, and evidence-based patient care.
Which Surgery Is Better for Pituitary Tumor Removal?
A randomised study finds pure endoscopic pituitary surgery improves goal achievement and pituitary function preservation versus microscopic, with similar long-term outcomes. PICO summary and commentary.
Do Antenatal Steroids Affect the Next Generation?
A 50-year follow-up of the Auckland Steroid Trial finds no transgenerational metabolic harm in the grandchildren of antenatal-steroid pregnancies. PICO summary and commentary.
Can combining semaglutide with metformin improve weight, metabolism, and fertility in women with PCOS?
An RCT finds adding semaglutide to metformin improves weight, testosterone, and natural pregnancy rates in women with PCOS. PICO summary and expert commentary.
Which Contrast Agent Is Better for MRI of Pituitary Macroadenomas?
A randomised comparison finds gadobutrol non-inferior to meglumine gadoterate for pituitary DCE-MRI but with a higher Kep to recognise, not a clear superiority. PICO summary and commentary.
Letrozole vs Programmed FET in PCOS: Comparable Pregnancy Rates, Simpler Luteal Support
An open-label multicentre RCT in 155 women with PCOS found that a letrozole ovulation regimen for frozen-thawed embryo transfer achieved clinical pregnancy rates comparable to a programmed regimen while requiring simpler luteal support. PICO summary and expert commentary.
Can MRI Track Hashimoto’s Thyroiditis Improvements After Diet Changes?
A small randomised study finds dietary management reduces quantitative thyroid MRI inflammation markers and antibodies in Hashimoto's thyroiditis, though the diet is unspecified. PICO summary and commentary.
Can Stem Cells Plus Shock Wave Therapy Treat Diabetic Erectile Dysfunction?
A small three-arm trial finds stem cells plus shock wave therapy outperform either alone for diabetic erectile dysfunction, a proof-of-concept result. PICO summary and commentary.